ADINA MAGDALENA TURCANU, DIANA VERONICA TURCU, IRINA DOBRIN, ANA CATERINA CRISTOFOR, VLADIMIR POROCH, ARMAND IUSTINIAN ENACHE ERYTHROCYTE SEDIMENTATION RATE AND TOTAL SERUM PROTEIN AS BIOCHEMICAL MARKERS OF ANXIETY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Chronic obstructive pulmonary disease (COPD) is a medical condition which is primarily characterized by airway inflammation and destruction of the pulmonary parenchyma. Besides the well-known physical comorbidities, psychological comorbidities such as anxiety have been found to be also increased in this category of patients. Our main three hypotheses referred to the biochemical markers of COPD (erythrocyte sedimentation rate- ESR, total serum protein and forced expiratory volume in the first second- FEV1) and their power of predicting the level of anxiety in this population. The study was conducted on 150 patients suffering from COPD. Based on their anxiety level, they were distributed in 2 groups: high anxiety and low anxiety. The results showed statistical significant differences between the two experimental groups regarding all three of our dependent variables, validating all of our three hypotheses. More specific, the patients in the high anxiety group had a significantly lower mean of FEV1 compared to low anxiety group (M = 46.01 vs. M = 41.47; p = 0.042). Also, patients from the high anxiety group had a significantly higher mean of total serum proteins compared to low anxiety group (M = 9.2 vs. M = 8.6; p = 0.002). And lastly, patients with high anxiety symptoms had a higher mean of ESR compared to those with low anxiety symptoms (M = 27.54 vs. M = 22.8; p = 0.045). Therefore, these biochemical markers commonly used in the diagnosing of COPD may be also used in predicting the severity of anxiety symptoms in this at risk group of patients.
Keywords: erythrocyte sedimentation rate (ESR), chronic obstructive pulmonary disease (COPD), forced expiratory volume in the first second (FEV1), total serum protein