GEORGETA ZEGAN, VASILICA TOMA, EDUARD RADU CERNEI, DANIELA ANISTOROAEI, ELENA MIHAELA CARAUSU, MIHAELA MOSCU STUDY ON ANTIBIOTIC LOADED NANOPARTICLES FOR ORAL INFECTION TREATMENT Over the past decade, exploitation of antimicrobial effect of nanoparticles on viruses, fungi and bacteria, respectively have developed markedly. A close attention was received by the possibility of nanoparticles type drug delivery systems to limit the biofilm formation within the oral cavity due to their important properties such as delivery abilities, anti-adhesive and biocidal features. The major objective of this work was to obtain doxycycline-loaded chitosan nanoparticles and to analyze the properties of as prepared samples in order to prolong the antibiotic release. The synthesized nanoparticles had less than 100 nm using the classis or improved drug encapsulation technique in chitosan matrix. The study focused on the antimicrobial characteristic of nanoparticles for controlling oral infections.
Keywords: doxycycline, nanoparticles, FTIR analysis, oral infections, orthodontics, pedodontics, public health dentistry, morphological