DAN ALIN BREBU, CRISTIAN VLAD, CRISTI TARTA, AMADEUS DOBRESCU, IULIANA MIHAIL, CRISTIAN NICA, LAZAR FULGER, CIPRIAN DUTA THE CORRELATION BETWEEN SPECIFIC BIOCHEMICAL PARAMETERS, RADIOLOGICAL DATA AND CLINICAL SINGS FOR PRACTICING LAPAROSCOPIC CHOLECYSTECTOMY IN THE FIRST 24 HOURS FOR ACUTE CHOLECYSTITIS. HOW SAFE IT IS? The best timing of cholecystectomy on patients with acute gallbladder pathology is still unclearly defined. Some studies have reported that cholecystectomy during the index acute admission presents an increased morbidity rate, extended duration of stay and increased costs. The study below is aiming at finding the most accurate moment to practice the surgery when acute cholecystitis is confirmed. Consequently, 368 patients admitted to hospital from January 2013 to December 2015 with the diagnosis of acute cholecystitis (AC) who underwent cholecystectomy in the 2nd Department of Surgery, Emergency County Hospital, Timiºoara, Romania constituted the two lots. The cases were retrospectively identified, introduced into the database and the data were subsequently analyzed according to various parameters. The study results reveal that laparoscopic cholecystectomy (LC) in the first 24 hours is safe procedure on the majority of the cases. Also, our findings sustain that emergency cholecystectomy can reduce the length of hospital stay, having similar rates of conversion to open surgery, complications and outcome compared with a delayed operation.