ANDREEA-LOREDANA GOLLI, FLOAREA MIMI NITU, MARIA BALASOIU, MARINA ALINA LUNGU, CRISTIANA CERASELLA DRAGOMIRESCU,MADALINA OLTEANU, ROXANA MARIA NEMES, MONICA MARILENA TANTU, MIHAI OLTEANU THE CHARACTERIZATION OF ANTIBIOTIC RESISTANCE OF BACTERIAL ISOLATES FROM INTENSIVE CARE UNIT PATIENT SAMPLES IN A UNIVERSITY AFFILIATED HOSPITAL IN ROMANIA To determine the resistance pattern of bacterial pathogens involved in infections of the patients aged between 18-64 years, admitted in a ICU from a 1518-bed university-affiliated hospital. A retrospective study of bacterial pathogens was carried out on 351 patients aged between 18-64 years admitted to the ICU, from January to December 2017. In this study there were analysed 469 samples from 351 patients (18-64 years). A total of 566 bacterial isolates were obtained, of which 120 strains of Klebsiella spp. (35.39%%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (75- 22.12%), Acinetobacter spp. (53 - 15.63%), Pseudomonas aeruginosa and Proteus (51 - 15.04%), and Escherichia coli (49 - 14.45%). The most common isolates were from respiratory tract (394 isolates – 69.61%). High rates of MDR were found for Pseudomonas aeruginosa (64.70%), MRSA (62.65%) and Klebsiella spp. (53.33%), while almost all of the isolated NFB strains were MDR (97.33%). There was statistic difference between the drug resistance rate of Klebsiella and E. coli strains to ceftazidime and ceftriaxone (p<0.001), cefuroxime (p<0.01) and to cefepime (p<0.01). The study revealed an alarming pattern of antibiotic resistance in the majority of ICU isolates.
Keywords: multidrug resistance (MDR), intensive care unit, bacterial pathogen