NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction

Lupaescu, Ancuta-Veronica; Sandu, Ion; Petre, Brindusa Alina; Ion, Laura; Ciobanu, Catalina-Ionica; Drochioiu, Gabi

Ancuta-Veronica Lupaescu, Ion Sandu, Brindusa Alina Petre, Laura Ion, Catalina-Ionica Ciobanu, Gabi Drochioiu

NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction

Abstract:

Neurodegenerative diseases, including Alzheimer disease, involve mechanisms such as protein aggregation, free radical generation and oxidative stress. Transition metals such as copper and iron were linked to neurodegenerative pathology. Their pathogenic role consists in generating different reactive oxygen species and damaging tissues or cells through the Fenton reaction. Abnormal metabolism of copper and iron can lead to several chronic pathogenesis. NAP is a small active fragment of activity-dependent neuroprotective protein essential for brain formation. NAP peptide showed neuroprotective proprieties against toxicity induced by the â-amyloid peptide, N-methyl-D-aspartate, electrical blockade, the envelope protein of the AIDS virus, dopamine, H2O2, and nutrient starvation in cell culture. Therefore, we investigated here the interaction of Cu2+ and Fe3+ ions with the NAP neuroprotective peptide and its analogs. With MALDI-ToF mass spectrometry, the formation of reduced metal-peptide complexes and the metal chelating properties of NAP-like neuroprotective peptides were highlighted.

Keywords:
NAP peptide; neuroprotection; copper; iron; MALDI-ToF MS

Issue: 2019, Volume 70, Issue 5

Pages: 1784-1790

Publication date: 2019/6/15

https://doi.org/10.37358/RC.19.5.7215

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUPAESCU, A., SANDU, I., PETRE, B.A., ION, L., CIOBANU, C., DROCHIOIU, G., NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction, Rev. Chim., 70(5), 2019, 1784-1790.

Vancouver
Lupaescu A, Sandu I, Petre BA, Ion L, Ciobanu C, Drochioiu G. NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction. Rev. Chim.[internet]. 2019 May;70(5):1784-1790. Available from: https://doi.org/10.37358/RC.19.5.7215

APA 6th edition
Lupaescu, A., Sandu, I., Petre, B.A., Ion, L., Ciobanu, C. & Drochioiu, G. (2019). NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction. Revista de Chimie, 70(5), 1784-1790. https://doi.org/10.37358/RC.19.5.7215

Harvard
Lupaescu, A., Sandu, I., Petre, B.A., Ion, L., Ciobanu, C., Drochioiu, G. (2019). 'NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction', Revista de Chimie, 70(5), pp. 1784-1790. https://doi.org/10.37358/RC.19.5.7215

IEEE
A. Lupaescu, I. Sandu, B.A. Petre, L. Ion, C. Ciobanu, G. Drochioiu, "NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction". Revista de Chimie, vol. 70, no. 5, pp. 1784-1790, 2019. [online]. https://doi.org/10.37358/RC.19.5.7215

Text
Ancuta-Veronica Lupaescu, Ion Sandu, Brindusa Alina Petre, Laura Ion, Catalina-Ionica Ciobanu, Gabi Drochioiu,
NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction,
Revista de Chimie,
Volume 70, Issue 5,
2019,
Pages 1784-1790,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.5.7215.
(https://revistadechimie.ro/Articles.asp?ID=7215)
Keywords: NAP peptide; neuroprotection; copper; iron; MALDI-ToF MS

RIS
TY - JOUR
T1 - NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction
A1 - Lupaescu, Ancuta-Veronica
A2 - Sandu, Ion
A3 - Petre, Brindusa Alina
A4 - Ion, Laura
A5 - Ciobanu, Catalina-Ionica
A6 - Drochioiu, Gabi
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 5
SP - 1784
EP - 1790
UR - https://doi.org/10.37358/RC.19.5.7215
KW - NAP peptide
KW - neuroprotection
KW - copper
KW - iron
KW - MALDI-ToF MS
ER -

BibTex
@article{RevCh2019P1784,
author = {Lupaescu Ancuta-Veronica and Sandu Ion and Petre Brindusa Alina and Ion Laura and Ciobanu Catalina-Ionica and Drochioiu Gabi},
title = {NAP Neuroprotective Peptide and its Analogs: Simultaneously Copper and Iron Binding and Reduction},
journal = {Revista de Chimie},
volume = {70},
number = {5},
pages = {1784-1790},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.5.7215},
url = {https://revistadechimie.ro/Articles.asp?ID=7215}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)