MIHAELA CRISTIANA COROI, LIANA TODOR, AUREL GEORGE MOHAN, LARISA BIANCA HOLHOS, AMINE BAKRAOUI, PAULA CRISTINA TODOR, SERGIU ANDREI TODOR, RAMONA AMINA POPOVICI TREATMENT WITH REGENERATING AGENT CACICOL® The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is demonstrated by numerous pathologies of acute or chronic injury associated with destruction or disruption of its components. Regenerating agent therapy (RGTA) showed a strong anti-oxidative and protective effect resulting in reduced inflammation in chronic periodontitis, corneal lesions, oral and skin ulcers <1-5>.Two cases of corneal healing with Cacicol®. The first one was a chemical corneal burn with persistent lesions which resulted in restitutio ad integrum after treatment with Cacicol®. The second case was a contact lens wearer whose cornea had an ulcer with profuse lesions within the stromal layer and the evolution under conventional treatment for 2 weeks was insignificant and after the use of Cacicol® the lesions improved. Cacicol® is an innovative treatment that can be used in non-healing corneal lesions, eg: unresponsive corneal burns with conventional treatment.