MARIA PROKS, ALINA HEGHES, ADELINA CHEVERESAN, SIMONA NITA, MIRELA VOICU, VALENTINA BUDA,DANIELA IONESCU, LUCIAN NITA, CRISTINA TRANDAFIRESCU, VIRGIL PAUNESCU THYME LEAVES AQUEOUS EXTRACT AND ITS FORMULATIONS A COMPARATIVE STUDY BASED ON CHEMICAL STRUCTURES AND BIOLOGICAL ACTIVITY The present study was conducted in order to evaluate the biological activity of thyme aqueous extract as compared to the silver nanoparticles obtained on it on four different cancer lines: non-melanoma skin cancer (A431 cell line), melanoma skin cancer (A375cell line), hormone dependent breast cancer (MCF-7 cell line), and non-hormone dependent breast cancer (MDA-MB-231 cell line). Of particular importance in the study of biological activity is the chemical composition. Formulas rich in compounds of classes like those of flavonoids are recognized for their efficacy and important antioxidant effect. The extract tested at various concentrations ranging from 10-1000 µg/mL exhibited a pronounced effect only on MCF-7 cells at the highest concentration tested and regarding the biosynthesized silver nanoparticles, the effect can be noted even at 1 ì M also only in the case of MCF-7 cells.
Keywords: thyme aqueous extract, green synthesis, silver, cytotoxicity