CARMEN GABRIELA STELEA, IULIAN CONSTANTIN, CRISTIAN BUDACU, ALEXANDRA LORINA PLATON, MIHAIL BALAN, LILIANA PAVEL, IOAN SIRBU, MIHAELA GABRIELA LUCA, MIHAI CONSTANTIN THE ROLE OF CHEMICAL AGENTS IN THE MICROBIAL FLORA WITH MAJOR RISK OF INTERVENTIOS IN MAXILO-FACIAL SURGERY The pathology of the oro-maxilo-facial territory comprises a vast chapter of diseases with primary or secondary infectious etiology, the mouth being the natural cavity of the organism with the most varied and variable flora of bacterial contamination. By the continuity solutions created by the mechanical act of mastication, decubitus of defective prosthetic works, local dento-periodontal infectious processes, but especially of dental or small-scale interventions, open gates and possibilities of penetration into the blood circulation of the microorganisms, which cause the transient bacteria. The study included 243 randomly selected patients, with the address of the Oral and Maxillofacial Surgery Clinic in the period 2016-2018. The inoculation of microorganisms in the oral cavity in circulating blood as a result of oral surgery or dental care procedures is much more common than in other areas of the body. Aggressive dental maneuvers that create solutions of continuity of oral mucosa, gingiva, periodontal surgery, periodontal surgery techniques can cause bacteria.