CATALIN ARANICIU, SMARANDA DAFINA ONIGA, CRISTINA IOANA STOICA, MARIANA CARMEN CHIFIRIUC, MARCELA POPA, LAURIAN VLASE, MARIANA PALAGE, OVIDIU ONIGA SYNTHESIS AND ANTIMICROBIAL ASSESSMENT OF SOME NEW 2-(THIAZOL-5-YL)-1,3,4-OXADIAZOLES
Considering the promising antimicrobial activity of compounds bearing the thiazole or the oxadiazole rings in their structures, we set out to obtain new antimicrobial molecules bearing the 2-(thiazol-5-yl)-1,3,4-oxadiazole schaffold. The structures of the 8 new compounds obtained was confirmed by physicochemical characterization including: 1H-NMR, MS and elemental analysis. Antimicrobial activity was investigated against 5 Gram-positive bacterial strains, 2 Gram-negative bacterial strains and 2 fungal strains. The newly synthesized compounds showed modest antimicrobial activity.