IRINA ESANU, IULIAN CONSTANTIN, CRISTIAN CONSTANTIN BUDACU, DORIANA AGOP FORNA, CONSTANTIN MIHAI THE ROLE OF CHEMICAL FACTORS IN THE DIABETES AND THE PREDIABETES THAT LEADS TO POLIMORFE ORO -MAXILO-FACIAL ALTERATIONS IN MALFORMATIVE SYNDROME There is no doubt that many psycho-emotional factors interfere with and produce changes in reproduction. Neglecting them means depriving our actions of efficiency because they will be incomplete. The adoption of the general term malformation syndrome to encompass all malformations draws attention on policy conditions set and communicate any teratologic process. Being a metabolic disease with clinical manifestations and multiple biochemical alterations, diabetes is a frightening scar of our century, considered to be the most important disease, which in itself leads to buccal-maxillo-facial polymorphic alterations. The study group consisted of 90 patients with congenital diabetes and stomatologic problems, aged between 26 and 65 years, the average age being 45 years. Distribution by gender: 60 men and30 women. Periodontal lesions are disturbing or distressing inflammation hyperplasic tissues of periodontium and quantity independence tissue affected to delineate both gingivitis and periodontitis. The most important factor in the epidemiology of the periodontal disease for prophylaxis is oral hygiene.