Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge

Chiriac, Florentina Laura; Paun, Iuliana; Pirvu, Florinela; Iancu, Vasile; Galaon, Toma

Florentina Laura Chiriac, Iuliana Paun, Florinela Pirvu, Vasile Iancu, Toma Galaon

Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge

Abstract:

In this study, a new LC-MS/MS method was developed and optimized in order to detect two omnipresent additives, Bisphenol A (BPA) and Butylhydroxyanisole (BHA), in WWTP sewage sludge. Both analytes are synthetic phenolic compounds known for their endocrine disruptive and toxic properties. BPA and BHA were isolated from sludge samples using ultrasonic assisted liquid-solid extraction followed by silicagel clean-up to remove interferences, and evaporation to dryness and extract re-dissolution with 1 mL methanol prior to LC-MS analysis. All LC-MS parameters were optimized in order to obtain high sensitivity and selectivity. MS detector response was linear in the range 1 ÷ 200 µg/L with correlation coefficient R2 ] 0.999 for both analytes. Intra-day and inter-day precision expressed as RSD values were 4.7% and 10.3% for BPA, whereas for BHA 7.8% and 13.8% RSD values were obtained. Recovery values after ultrasonic assisted extraction were 85.5% for BPA and 79.3% BHA with internal standard correction. Overall method LOQs were established at 1.97 ng/g (BPA) and 1.86 ng/g (BHA) on dry weight. Optimized chromatographic parameters allowed separation and detection of the two additives in less than 10 minutes. Both BPA and BHA were detected in all tested sludge samples with higher levels for BPA (34.6 - 132.6 ng/g), whereas BHA was found at lower levels in the range 3.16 - 5.64 ng/g.

Keywords:
Additives; BPA; BHA; LC-MS; ultrasonic assisted liquid-solid extraction; WWTP sewage sludge

Issue: 2019, Volume 70, Issue 6

Pages: 2123-2127

Publication date: 2019/7/15

https://doi.org/10.37358/RC.19.6.7288

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CHIRIAC, F.L., PAUN, I., PIRVU, F., IANCU, V., GALAON, T., Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge, Rev. Chim., 70(6), 2019, 2123-2127.

Vancouver
Chiriac FL, Paun I, Pirvu F, Iancu V, Galaon T. Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge. Rev. Chim.[internet]. 2019 Jun;70(6):2123-2127. Available from: https://doi.org/10.37358/RC.19.6.7288

APA 6th edition
Chiriac, F.L., Paun, I., Pirvu, F., Iancu, V. & Galaon, T. (2019). Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge. Revista de Chimie, 70(6), 2123-2127. https://doi.org/10.37358/RC.19.6.7288

Harvard
Chiriac, F.L., Paun, I., Pirvu, F., Iancu, V., Galaon, T. (2019). 'Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge', Revista de Chimie, 70(6), pp. 2123-2127. https://doi.org/10.37358/RC.19.6.7288

IEEE
F.L. Chiriac, I. Paun, F. Pirvu, V. Iancu, T. Galaon, "Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge". Revista de Chimie, vol. 70, no. 6, pp. 2123-2127, 2019. [online]. https://doi.org/10.37358/RC.19.6.7288

Text
Florentina Laura Chiriac, Iuliana Paun, Florinela Pirvu, Vasile Iancu, Toma Galaon,
Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge,
Revista de Chimie,
Volume 70, Issue 6,
2019,
Pages 2123-2127,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.6.7288.
(https://revistadechimie.ro/Articles.asp?ID=7288)
Keywords: Additives; BPA; BHA; LC-MS; ultrasonic assisted liquid-solid extraction; WWTP sewage sludge

RIS
TY - JOUR
T1 - Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge
A1 - Chiriac, Florentina Laura
A2 - Paun, Iuliana
A3 - Pirvu, Florinela
A4 - Iancu, Vasile
A5 - Galaon, Toma
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 6
SP - 2123
EP - 2127
UR - https://doi.org/10.37358/RC.19.6.7288
KW - Additives
KW - BPA
KW - BHA
KW - LC-MS
KW - ultrasonic assisted liquid-solid extraction
KW - WWTP sewage sludge
ER -

BibTex
@article{RevCh2019P2123,
author = {Chiriac Florentina Laura and Paun Iuliana and Pirvu Florinela and Iancu Vasile and Galaon Toma},
title = {Fast and Sensitive LC-MS Detection of Bisphenol A and Butylhydroxyanisole in WWTP Sewage Sludge},
journal = {Revista de Chimie},
volume = {70},
number = {6},
pages = {2123-2127},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.6.7288},
url = {https://revistadechimie.ro/Articles.asp?ID=7288}
}

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