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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 6, 2128-2131

https://doi.org/10.37358/RC.19.6.7289

Oana Criciotoiu, Diana Iulia Stanca, Simona Bondari, Ramona-Denise Malin, Mircea-Sorin Ciolofan, Michael Schenker, Mioara Desdemona Stepan, Florin Marius Romanescu, Ovidiu Stefan Georgescu, Lucian Paul Dragomir, Victor Gheorman, Veronica Gheorman, Dan Ionut Gheonea

Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease

Abstract:

Levodopa (L-dopa), a precursor of dopamine, remained the gold standard among antiparkinsonian drugs and virtually, in different stages, all patients will require the more powerful symptomatic effect of L-dopa. In addition, continuous Levodopa/Carbidopa intestinal gel (LCIG) infusion therapy, via a percutaneous endoscopic gastrostomy (PEG) and a portable infusion pump, is well established for the treatment of advanced Parkinson’s disease (PD), substantially improving motor symptoms and quality of life in these patients. This study aimed to evaluate the necessity of LCGI depending the PD motor subtypes and age at onset of the disease. Seventy patients diagnosed with PD were included in our study. The Unified Parkinson’s Disease Rating Scale (UPDRS) was performed in on state. The patients were classified as tremor-dominant type (TDT), akinetic-rigid type (ART) and mixed type (MT). Depending on form of levodopa, thirty-six patients were on L-dopa orally and thirty-four patients were on LCIG. The results of our study showed that there was a statistically significant correlation between the age at onset of PD and the motor subtype of the disease. Also, we observed that the lower the age at diagnosis, the more our patients have reached the need for LCGI. Regarding the motor subtype, our study showed that the mixed typed request more frequent LCGI. Our data show that age and motor profile at onset can predict the necessity of advanced therapy.
Keywords:
levodopa; oral administration; intrajejunal gel; Parkinson disease; age

Issue: 2019, Volume 70, Issue 6
Pages: 2128-2131
Publication date: 2019/7/15
https://doi.org/10.37358/RC.19.6.7289
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CRICIOTOIU, O., STANCA, D.I., BONDARI, S., MALIN, R., CIOLOFAN, M., SCHENKER, M., STEPAN, M.D., ROMANESCU, F.M., GEORGESCU, O.S., DRAGOMIR, L.P., GHEORMAN, V., GHEORMAN, V., GHEONEA, D.I., Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease, Rev. Chim., 70(6), 2019, 2128-2131.

Vancouver
Criciotoiu O, Stanca DI, Bondari S, Malin R, Ciolofan M, Schenker M, Stepan MD, Romanescu FM, Georgescu OS, Dragomir LP, Gheorman V, Gheorman V, Gheonea DI. Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease. Rev. Chim.[internet]. 2019 Jun;70(6):2128-2131. Available from: https://doi.org/10.37358/RC.19.6.7289


APA 6th edition
Criciotoiu, O., Stanca, D.I., Bondari, S., Malin, R., Ciolofan, M., Schenker, M.,... Gheonea, D.I. (2019). Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease. Revista de Chimie, 70(6), 2128-2131. https://doi.org/10.37358/RC.19.6.7289


Harvard
Criciotoiu, O., Stanca, D.I., Bondari, S., Malin, R., Ciolofan, M., Schenker, M., Stepan, M.D., Romanescu, F.M., Georgescu, O.S., Dragomir, L.P., Gheorman, V., Gheorman, V., Gheonea, D.I. (2019). 'Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease', Revista de Chimie, 70(6), pp. 2128-2131. https://doi.org/10.37358/RC.19.6.7289


IEEE
O. Criciotoiu, D.I. Stanca, S. Bondari, R. Malin, M. Ciolofan, M. Schenker, M.D. Stepan, F.M. Romanescu, O.S. Georgescu, L.P. Dragomir, V. Gheorman, V. Gheorman, D.I. Gheonea, "Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease". Revista de Chimie, vol. 70, no. 6, pp. 2128-2131, 2019. [online]. https://doi.org/10.37358/RC.19.6.7289


Text
Oana Criciotoiu, Diana Iulia Stanca, Simona Bondari, Ramona-Denise Malin, Mircea-Sorin Ciolofan, Michael Schenker, Mioara Desdemona Stepan, Florin Marius Romanescu, Ovidiu Stefan Georgescu, Lucian Paul Dragomir, Victor Gheorman, Veronica Gheorman, Dan Ionut Gheonea,
Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease,
Revista de Chimie,
Volume 70, Issue 6,
2019,
Pages 2128-2131,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.6.7289.
(https://revistadechimie.ro/Articles.asp?ID=7289)
Keywords: levodopa; oral administration; intrajejunal gel; Parkinson disease; age


RIS
TY - JOUR
T1 - Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease
A1 - Criciotoiu, Oana
A2 - Stanca, Diana Iulia
A3 - Bondari, Simona
A4 - Malin, Ramona-Denise
A5 - Ciolofan, Mircea-Sorin
A6 - Schenker, Michael
A7 - Stepan, Mioara Desdemona
A8 - Romanescu, Florin Marius
A9 - Georgescu, Ovidiu Stefan
A10 - Dragomir, Lucian Paul
A11 - Gheorman, Victor
A12 - Gheorman, Veronica
A13 - Gheonea, Dan Ionut
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 6
SP - 2128
EP - 2131
UR - https://doi.org/10.37358/RC.19.6.7289
KW - levodopa
KW - oral administration
KW - intrajejunal gel
KW - Parkinson disease
KW - age
ER -


BibTex
@article{RevCh2019P2128,
author = {Criciotoiu Oana and Stanca Diana Iulia and Bondari Simona and Malin Ramona-Denise and Ciolofan Mircea-Sorin and Schenker Michael and Stepan Mioara Desdemona and Romanescu Florin Marius and Georgescu Ovidiu Stefan and Dragomir Lucian Paul and Gheorman Victor and Gheorman Veronica and Gheonea Dan Ionut},
title = {Correlation Between the Age, Motor Subtypes and the Necessity of Advanced Therapy in Parkinson Disease},
journal = {Revista de Chimie},
volume = {70},
number = {6},
pages = {2128-2131},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.6.7289},
url = {https://revistadechimie.ro/Articles.asp?ID=7289}
}
 
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