DOINA GEORGESCU, MIRCEA IURCIUC, IOANA IONITA, LIVIU-ANDREI GEORGESCU, MIHAELA MUNTEAN, ANA LASCU, MIHAI IONITA, DANIEL LIGHEZAN PORTAL VEIN THROMBOSIS AND GUT MICROBIOTA: UNDERSTANDING THE BURDEN Portal vein thrombosis (PVT) continues to be challenging, due to its versatile features and associated clinical pitfalls. This study aimed to explore whether gut microbiota imbalance (GMI) could alter clinical presentation and short term outcome in cirrhotic patients with PVT. We conducted a cross-sectional exploratory study, concerning 50 consecutive cirrhotic patients with PVT recruited during hospitalization. Consecutive to stool microbiological exams, they were assigned into two groups: 25 GMI positive as study group and 25 GMI negative as comparison group. Clinical examination, laboratory work–ups, upper and lower digestive endoscopy, abdominal Duplex ultrasound and CT/MRI were performed Results: Study group displayed significant differences concerning age, interleukin-10 and albumin levels, digestive bleeding, abdominal pain severity and longer hospitalization. In conclusion, dysbiotic patients displayed clinical particularities characterized by older age, higher inflammatory status, hypoalbuminemia, more severe PVT, abdominal pain and digestive bleeding, as well as longer hospitalization duration.