The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function

Coculescu, Bogdan Ioan; Manole, Gheorghe; Dinca, Alexandra-Ligia; Harsovescu, Tudor; Tudorache, Ioan Sorin

Bogdan Ioan Coculescu, Gheorghe Manole, Alexandra-Ligia Dinca, Tudor Harsovescu, Ioan Sorin Tudorache

The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function

Abstract:

The present study looks at serum concentration levels of myeloperoxidase (MPO) and high-sensibility C Reactive Protein (hs-PCR) concentrations in 91 patients who presented thoracic pain localised on the sub-clavicular left side, which bothered them several times a day, where an episode lasted up to 30 minutes. Additional preclinical investigations revealed normal resting state/effort electrocardiograms, and the cardiac ultrasound revealed a diastolic cardiac dysfunction with a conserved ejection fraction. The conclusion of our study is that undertaking the exploratory tetrad (electrocardiogram, echocardiogram, serum dosage of MPO and hs-PCR) in patients who present anterior left pain, regardless of the degree of intensity, allows stratifying risks, at least through early detection of an existent diastolic cardiac dysfunction with conserved ejection fraction, which recommends changes in diet and lifestyle along with therapy.

Keywords:
reactive oxygen species (ROS); reactive nitrogen species (RNS); myeloperoxidase (MPO); high-sensibility C Reactive Protein (hs-CRP)

Issue: 2019, Volume 70, Issue 6

Pages: 2229-2231

Publication date: 2019/7/15

https://doi.org/10.37358/RC.19.6.7311

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
COCULESCU, B.I., MANOLE, G., DINCA, A., HARSOVESCU, T., TUDORACHE, I.S., The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function, Rev. Chim., 70(6), 2019, 2229-2231.

Vancouver
Coculescu BI, Manole G, Dinca A, Harsovescu T, Tudorache IS. The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function. Rev. Chim.[internet]. 2019 Jun;70(6):2229-2231. Available from: https://doi.org/10.37358/RC.19.6.7311

APA 6th edition
Coculescu, B.I., Manole, G., Dinca, A., Harsovescu, T. & Tudorache, I.S. (2019). The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function. Revista de Chimie, 70(6), 2229-2231. https://doi.org/10.37358/RC.19.6.7311

Harvard
Coculescu, B.I., Manole, G., Dinca, A., Harsovescu, T., Tudorache, I.S. (2019). 'The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function', Revista de Chimie, 70(6), pp. 2229-2231. https://doi.org/10.37358/RC.19.6.7311

IEEE
B.I. Coculescu, G. Manole, A. Dinca, T. Harsovescu, I.S. Tudorache, "The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function". Revista de Chimie, vol. 70, no. 6, pp. 2229-2231, 2019. [online]. https://doi.org/10.37358/RC.19.6.7311

Text
Bogdan Ioan Coculescu, Gheorghe Manole, Alexandra-Ligia Dinca, Tudor Harsovescu, Ioan Sorin Tudorache,
The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function,
Revista de Chimie,
Volume 70, Issue 6,
2019,
Pages 2229-2231,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.6.7311.
(https://revistadechimie.ro/Articles.asp?ID=7311)
Keywords: reactive oxygen species (ROS); reactive nitrogen species (RNS); myeloperoxidase (MPO); high-sensibility C Reactive Protein (hs-CRP)

RIS
TY - JOUR
T1 - The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function
A1 - Coculescu, Bogdan Ioan
A2 - Manole, Gheorghe
A3 - Dinca, Alexandra-Ligia
A4 - Harsovescu, Tudor
A5 - Tudorache, Ioan Sorin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 6
SP - 2229
EP - 2231
UR - https://doi.org/10.37358/RC.19.6.7311
KW - reactive oxygen species (ROS)
KW - reactive nitrogen species (RNS)
KW - myeloperoxidase (MPO)
KW - high-sensibility C Reactive Protein (hs-CRP)
ER -

BibTex
@article{RevCh2019P2229,
author = {Coculescu Bogdan Ioan and Manole Gheorghe and Dinca Alexandra-Ligia and Harsovescu Tudor and Tudorache Ioan Sorin},
title = {The Possible Serum Complex-Biomarkers for the Early Diagnosis of Diastolic Dysfunction with Preserved Systolic Function},
journal = {Revista de Chimie},
volume = {70},
number = {6},
pages = {2229-2231},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.6.7311},
url = {https://revistadechimie.ro/Articles.asp?ID=7311}
}

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