BOGDAN IOAN COCULESCU, GHEORGHE MANOLE, ALEXANDRA-LIGIA DINCA, TUDOR HARSOVESCU, IOAN SORIN TUDORACHE THE POSSIBLE SERUM COMPLEX-BIOMARKERS FOR THE EARLY DIAGNOSIS OF DIASTOLIC DYSFUNCTION WITH PRESERVED SYSTOLIC FUNCTION
The present study looks at serum concentration levels of myeloperoxidase (MPO) and high-sensibility C Reactive Protein (hs-PCR) concentrations in 91 patients who presented thoracic pain localised on the sub-clavicular left side, which bothered them several times a day, where an episode lasted up to 30 minutes. Additional preclinical investigations revealed normal resting state/effort electrocardiograms, and the cardiac ultrasound revealed a diastolic cardiac dysfunction with a conserved ejection fraction. The conclusion of our study is that undertaking the exploratory tetrad (electrocardiogram, echocardiogram, serum dosage of MPO and hs-PCR) in patients who present anterior left pain, regardless of the degree of intensity, allows stratifying risks, at least through early detection of an existent diastolic cardiac dysfunction with conserved ejection fraction, which recommends changes in diet and lifestyle along with therapy.
Keywords: reactive oxygen species (ROS), reactive nitrogen species (RNS), myeloperoxidase (MPO), high-sensibility C Reactive Protein (hs-CRP)