MARIANA STUPARU CRETU, CAMELIA BUSILA, LILIANA CARAMAN, GABRIELA BALAN, ALINA MIHAELA CALIN THE ESTIMATED ADOLESCENTS’CARBOHYDRATE METABOLISM AND INSULIN RESISTANCE IN PCOS The Polycystic Ovary Syndrome (PCOS) represents a recognised entity within the female medical conditions today. The multidisciplinary aspects refer to various and variable symptomatology, which mainly associates the reproductive problems with clinical signs of hyper-androgyny and metabolic disorders, frequently associated with obesity. The present study demonstrates the existence of some carbohydrate metabolic anomalies in adolescents diagnosed with PCOS which had remained asymptomatic and undiagnosed prior to the analysis. It is thus suggested that metabolic testing is necessary for adolescents diagnosed with PCOS, even if they are neither overweight nor part of the definition criteria. It is important for the therapeutic interventions to analyse the DM2 intermediary risk markers, as the oral glucose tolerance test (OGTT) repeated 3 hours after glucose powder dose ingestion is informative of the persistent hyperglycaemia and the decrease in pancreatic function.