CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?

Dadarlat, Alexandra; Pop, Dana; Farcas, Anca Daniela; Zdrenghea, Dumitru; Bodizs, Gyorgy; Tomoaia, Raluca; Gurzu, Diana; Susca-Hojda, Silvana; Fringu, Florina; Buzoianu, Anca Dana

Alexandra Dadarlat, Dana Pop, Anca Daniela Farcas, Dumitru Zdrenghea, Gyorgy Bodizs, Raluca Tomoaia, Diana Gurzu, Silvana Susca-Hojda, Florina Fringu, Anca Dana Buzoianu

CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?

Abstract:

Heart failure continues to be a major worldwide medical issue, associated with high morbidity and mortality. The need for ideal biomarkers to aid the diagnosis and prognosis in certain situations, such as obesity or atrial fibrillation is still ongoing. Obese patients are commonly hyperleptinemic. The aim of the study is to assess the role of several biomarkers in overweight and obese patients diagnosed with heart failure, depending on the presence or absence of atrial fibrillation and also their relationship with leptin. The study included 88 overweight and obese patients, with a body mass index (BMI) ≥25 kg/m2, admitted for worsening heart failure. Of these, 52.2% had atrial fibrillation. Dosage of NT-proBNP was performed using the chemiluminescence method. MR-proANP, galectin-3 and leptin were dosed using the ELISA method. A value of P [0.05 was defined as statistically significant. The values of natriuretic peptides NT-proBNP and MR-proANP were significantly increased. Only NT-proBNP was significantly influenced by renal function. No statistically significant correlation was found between heart failure-specific biomarkers and leptin secretion. There were no significant differences in the biomarkers levels between the 2 groups of patients. No statistically significant correlation was found between heart failure-specific biomarkers and leptin secretion. Obese patients with heart failure had significantly increased values of all the studied parameters, but the presence of atrial fibrillation did not influence their levels. High leptin levels were not directly correlated with the levels of heart failure-specific biomarkers.

Keywords:
heart failure; biomarkers; obesity; atrial fibrillation

Issue: 2019, Volume 70, Issue 6

Pages: 2294-2300

Publication date: 2019/7/15

https://doi.org/10.37358/RC.19.6.7326

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DADARLAT, A., POP, D., FARCAS, A.D., ZDRENGHEA, D., BODIZS, G., TOMOAIA, R., GURZU, D., SUSCA-HOJDA, S., FRINGU, F., BUZOIANU, A.D., CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?, Rev. Chim., 70(6), 2019, 2294-2300.

Vancouver
Dadarlat A, Pop D, Farcas AD, Zdrenghea D, Bodizs G, Tomoaia R, Gurzu D, Susca-Hojda S, Fringu F, Buzoianu AD. CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?. Rev. Chim.[internet]. 2019 Jun;70(6):2294-2300. Available from: https://doi.org/10.37358/RC.19.6.7326

APA 6th edition
Dadarlat, A., Pop, D., Farcas, A.D., Zdrenghea, D., Bodizs, G., Tomoaia, R.,... Buzoianu, A.D. (2019). CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?. Revista de Chimie, 70(6), 2294-2300. https://doi.org/10.37358/RC.19.6.7326

Harvard
Dadarlat, A., Pop, D., Farcas, A.D., Zdrenghea, D., Bodizs, G., Tomoaia, R., Gurzu, D., Susca-Hojda, S., Fringu, F., Buzoianu, A.D. (2019). 'CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?', Revista de Chimie, 70(6), pp. 2294-2300. https://doi.org/10.37358/RC.19.6.7326

IEEE
A. Dadarlat, D. Pop, A.D. Farcas, D. Zdrenghea, G. Bodizs, R. Tomoaia, D. Gurzu, S. Susca-Hojda, F. Fringu, A.D. Buzoianu, "CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?". Revista de Chimie, vol. 70, no. 6, pp. 2294-2300, 2019. [online]. https://doi.org/10.37358/RC.19.6.7326

Text
Alexandra Dadarlat, Dana Pop, Anca Daniela Farcas, Dumitru Zdrenghea, Gyorgy Bodizs, Raluca Tomoaia, Diana Gurzu, Silvana Susca-Hojda, Florina Fringu, Anca Dana Buzoianu,
CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?,
Revista de Chimie,
Volume 70, Issue 6,
2019,
Pages 2294-2300,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.6.7326.
(https://revistadechimie.ro/Articles.asp?ID=7326)
Keywords: heart failure; biomarkers; obesity; atrial fibrillation

RIS
TY - JOUR
T1 - CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?
A1 - Dadarlat, Alexandra
A2 - Pop, Dana
A3 - Farcas, Anca Daniela
A4 - Zdrenghea, Dumitru
A5 - Bodizs, Gyorgy
A6 - Tomoaia, Raluca
A7 - Gurzu, Diana
A8 - Susca-Hojda, Silvana
A9 - Fringu, Florina
A10 - Buzoianu, Anca Dana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 6
SP - 2294
EP - 2300
UR - https://doi.org/10.37358/RC.19.6.7326
KW - heart failure
KW - biomarkers
KW - obesity
KW - atrial fibrillation
ER -

BibTex
@article{RevCh2019P2294,
author = {Dadarlat Alexandra and Pop Dana and Farcas Anca Daniela and Zdrenghea Dumitru and Bodizs Gyorgy and Tomoaia Raluca and Gurzu Diana and Susca-Hojda Silvana and Fringu Florina and Buzoianu Anca Dana},
title = {CAN THE PRESENCE OF ATRIAL FIBRILLATION INFLUENCE THE LEVELS OF HEART FAILURE - SPECIFIC BIOMARKERS IN OVERWEIGHT AND OBESE PATIENTS WITH HEART FAILURE?},
journal = {Revista de Chimie},
volume = {70},
number = {6},
pages = {2294-2300},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.6.7326},
url = {https://revistadechimie.ro/Articles.asp?ID=7326}
}

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