RAMONA-DANIELA PAVALOIU, FAWZIA SHA AT, CORINA BUBUEANU, CRISTINA HLEVCA, GHEORGHE NECHIFOR DESIGN AND EVALUATION OF A DELIVERY SYSTEM BASED ON LIPOSOMES FOR ARMORACIA RUSTICANA EXTRACT The aim of this paper was the design and evaluation of delivery system for Armoracia rusticana leaves extract with the purpose to use such systems in food or cosmetic field. Liposomes loaded with Armoracia rusticana were prepared by film hydration method and presented good entrapment efficiency, nano-sizes (<150 nm), low polydispersity index and good stability over 90 days at 4oC. In vitro drug release study showed the ability of liposomes to provide slow release of extract with reduced burst effect compared to free extract. These promising results suggest that liposomes could be exploited as carriers for herbal ingredients.
Keywords: Armoracia rusticana, liposomes, drug delivery systems, encapsulation