Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer

Zgura, Anca; Gales, Laurentia; Haineala, Bogdan; Bratila, Elvira; Mehedintu, Claudia; Andreescu, Cristina Veronica; Berceanu, Costin; Petca, Aida; Barac, Ramona Ileana; Ionescu, Alec; Anghe, Rodica

Anca Zgura, Laurentia Gales, Bogdan Haineala, Elvira Bratila, Claudia Mehedintu, Cristina Veronica Andreescu, Costin Berceanu, Aida Petca, Ramona Ileana Barac, Alec Ionescu, Rodica Anghe

Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer

Abstract:

The presence of tumor-infiltrating lymphocytes (TILs) is associated with a favorable long-term outcome in breast cancer. The main objective of this study was to show that there is a correlation between known prognostic and predictive factors and TILs. We retrospectively identified 56 patients with human epidermal growth factor receptor-2 (HER2 +, n = 22) and HER2 negative (HER2-, n = 34) breast cancer diagnosed between 2012 and 2018 at the Institute of Oncology Prof. Dr. Alexandru Trestioreanu, Bucharest. Hematoxylin-eosin-stained slides of these paired samples were evaluated for stromal TILs. The present study reports that TILs can be used as a clinically useful biomarker that has the ability to stratify HER2 negative and HER2 positive patients in prognostic function, bringing relevant information in addition to the established prognostic factors.

Keywords:
Immune microenvironment; immunohistochemistry; metastatic breast tumor; primary breast tumor; tumor-inûltrating lymphocytes

Issue: 2019, Volume 70, Issue 7

Pages: 2362-2366

Publication date: 2019/8/15

https://doi.org/10.37358/RC.19.7.7340

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ZGURA, A., GALES, L., HAINEALA, B., BRATILA, E., MEHEDINTU, C., ANDREESCU, C.V., BERCEANU, C., PETCA, A., BARAC, R.I., IONESCU, A., ANGHE, R., Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer, Rev. Chim., 70(7), 2019, 2362-2366.

Vancouver
Zgura A, Gales L, Haineala B, Bratila E, Mehedintu C, Andreescu CV, Berceanu C, Petca A, Barac RI, Ionescu A, Anghe R. Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer. Rev. Chim.[internet]. 2019 Jul;70(7):2362-2366. Available from: https://doi.org/10.37358/RC.19.7.7340

APA 6th edition
Zgura, A., Gales, L., Haineala, B., Bratila, E., Mehedintu, C., Andreescu, C.V.,... Anghe, R. (2019). Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer. Revista de Chimie, 70(7), 2362-2366. https://doi.org/10.37358/RC.19.7.7340

Harvard
Zgura, A., Gales, L., Haineala, B., Bratila, E., Mehedintu, C., Andreescu, C.V., Berceanu, C., Petca, A., Barac, R.I., Ionescu, A., Anghe, R. (2019). 'Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer', Revista de Chimie, 70(7), pp. 2362-2366. https://doi.org/10.37358/RC.19.7.7340

IEEE
A. Zgura, L. Gales, B. Haineala, E. Bratila, C. Mehedintu, C.V. Andreescu, C. Berceanu, A. Petca, R.I. Barac, A. Ionescu, R. Anghe, "Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer". Revista de Chimie, vol. 70, no. 7, pp. 2362-2366, 2019. [online]. https://doi.org/10.37358/RC.19.7.7340

Text
Anca Zgura, Laurentia Gales, Bogdan Haineala, Elvira Bratila, Claudia Mehedintu, Cristina Veronica Andreescu, Costin Berceanu, Aida Petca, Ramona Ileana Barac, Alec Ionescu, Rodica Anghe,
Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2362-2366,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7340.
(https://revistadechimie.ro/Articles.asp?ID=7340)
Keywords: Immune microenvironment; immunohistochemistry; metastatic breast tumor; primary breast tumor; tumor-inûltrating lymphocytes

RIS
TY - JOUR
T1 - Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer
A1 - Zgura, Anca
A2 - Gales, Laurentia
A3 - Haineala, Bogdan
A4 - Bratila, Elvira
A5 - Mehedintu, Claudia
A6 - Andreescu, Cristina Veronica
A7 - Berceanu, Costin
A8 - Petca, Aida
A9 - Barac, Ramona Ileana
A10 - Ionescu, Alec
A11 - Anghe, Rodica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2362
EP - 2366
UR - https://doi.org/10.37358/RC.19.7.7340
KW - Immune microenvironment
KW - immunohistochemistry
KW - metastatic breast tumor
KW - primary breast tumor
KW - tumor-inûltrating lymphocytes
ER -

BibTex
@article{RevCh2019P2362,
author = {Zgura Anca and Gales Laurentia and Haineala Bogdan and Bratila Elvira and Mehedintu Claudia and Andreescu Cristina Veronica and Berceanu Costin and Petca Aida and Barac Ramona Ileana and Ionescu Alec and Anghe Rodica},
title = {Correlations Between Known Prognostic Markers and Tumor - infiltrating Lymphocytes in Breast Cancer},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2362-2366},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7340},
url = {https://revistadechimie.ro/Articles.asp?ID=7340}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)