ANDREI LESAN, MILENA ADINA MAN, ROXANA MARIA NEMES, TUDOR HARSOVESCU, IOAN SORIN TUDORACHE, BEATRICE MAHLER BOCA, CARMEN MONICA POP SERUM INTERLEUKIN 4 AND 6 LEVELS MEASURED USING THE ELISA METHOD IN PATIENTS WITH ACQUIRED BRONCHIECTASIS COMPARED TO HEALTHY SUBJECTS. AN ANTI-INFLAMMATORY AND PRO-INFLAMMATORY RELATION Evaluation of the inflammatory response based on the Interleukin 4 and Interleukin 6 levels in patients with acquired bronchiectasis (non-cystic fibrosis) and healthy controls. The study was conducted on a group of 77 subjects, divided into 2 lots: the first lot consisting of 57 patients with acquired bronchiectasis objectified by Computed Tomography and 20 healthy individuals. The serum Interleukins 4 and 6 levels were measured using the ELISA biochemical spectrophotometry test. The results are significant from a statistical point of view, especially when it comes to the mean value of Interleukin 4 that was much higher in the control lot. Interleukin 4 is a proinflammatory cytokine and therefore we can draw the conclusion that to some extent bronchiectasis can be associated with an immunodeficiency disorder prior to the pathology itself or it can be caused by the pathology. Future research is open in this field for the analysis of interleukin levels in bronchioloalveolar lavage compared to serum levels.
Keywords: bronchiectasis, non-cystic fibrosis, interleukins 4 and 6, anti-inflammatory, pro-inflammatory