Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment

Ciorba, Nicoleta Craciun; Ciorba, Ilie Marius; Puiac, Ion Claudiu; Bancu, Ligia Ariana

Nicoleta Craciun Ciorba, Ilie Marius Ciorba, Ion Claudiu Puiac, Ligia Ariana Bancu

Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment

Abstract:

The World Health Organization (WHO) estimates that 170 million individuals worldwide are infected with hepatitis C virus (HCV). The aim of study was to evaluate possible correlations between METAVIR staging, the viral loads and alanine aminotransferase (ALT) levels in patients with chronic hepatitis C, before and after 12 weeks of treatment with PegInterferon a2a/a2b and Ribavirin. 93 consecutive patients with hepatitis C, were included in this study. The parameters followed were age, sex, Metavir histologic staging at the start of the treatment, hepatitis C virus ribonucleic acid (HCV-RNA) and ALT at start and after 12 weeks of treatment, as well as alcohol intake. The study group was composed by 58 women and 35 men, with a mean age of 44.47 ± 11.17 years. At the beginning of the treatment, the mean value of HCV-RNA was 1327163 ± 145001 UI/mL, with a CI95%=1327163 ± 287986.36 UI/mL, and the mean value for ALT was 112.7124 ± 68.7403 U/l. After 12 weeks of therapy, significant differences were found concerning both HCV-RNA and ALT values. HCV-RNA lowered to a mean value of 457.3978 ± 402.653 (p[0.0001), while ALT lowered to a mean value of 37.90 ± 16.43U/l (p[0.0001). Neither the initial HCV-RNA nor ALT values had any correlations with the METAVIR histological staging of the fibrosis. Initial ALT was higher in those with alcohol intake (p=0.000048). The ALT values instead, after 3 months of treatment, decreased significantly (p[0.0001), did correlate with the METAVIR groups (p=0.0019). The evolutionary stage of fibrosis didn’t correlate with gender of the patients or initial values of the HCV-RNA or ALT. There was no correlation between the age/gender of the patients and the determined METAVIR score.

Keywords:
METAVIR staging; HCV RNA; ALT; PegInterferon; Ribavirin

Issue: 2019, Volume 70, Issue 7

Pages: 2420-2424

Publication date: 2019/8/15

https://doi.org/10.37358/RC.19.7.7353

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CIORBA, N.C., CIORBA, I.M., PUIAC, I.C., BANCU, L.A., Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment, Rev. Chim., 70(7), 2019, 2420-2424.

Vancouver
Ciorba NC, Ciorba IM, Puiac IC, Bancu LA. Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment. Rev. Chim.[internet]. 2019 Jul;70(7):2420-2424. Available from: https://doi.org/10.37358/RC.19.7.7353

APA 6th edition
Ciorba, N.C., Ciorba, I.M., Puiac, I.C. & Bancu, L.A. (2019). Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment. Revista de Chimie, 70(7), 2420-2424. https://doi.org/10.37358/RC.19.7.7353

Harvard
Ciorba, N.C., Ciorba, I.M., Puiac, I.C., Bancu, L.A. (2019). 'Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment', Revista de Chimie, 70(7), pp. 2420-2424. https://doi.org/10.37358/RC.19.7.7353

IEEE
N.C. Ciorba, I.M. Ciorba, I.C. Puiac, L.A. Bancu, "Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment". Revista de Chimie, vol. 70, no. 7, pp. 2420-2424, 2019. [online]. https://doi.org/10.37358/RC.19.7.7353

Text
Nicoleta Craciun Ciorba, Ilie Marius Ciorba, Ion Claudiu Puiac, Ligia Ariana Bancu,
Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2420-2424,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7353.
(https://revistadechimie.ro/Articles.asp?ID=7353)
Keywords: METAVIR staging; HCV RNA; ALT; PegInterferon; Ribavirin

RIS
TY - JOUR
T1 - Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment
A1 - Ciorba, Nicoleta Craciun
A2 - Ciorba, Ilie Marius
A3 - Puiac, Ion Claudiu
A4 - Bancu, Ligia Ariana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2420
EP - 2424
UR - https://doi.org/10.37358/RC.19.7.7353
KW - METAVIR staging
KW - HCV RNA
KW - ALT
KW - PegInterferon
KW - Ribavirin
ER -

BibTex
@article{RevCh2019P2420,
author = {Ciorba Nicoleta Craciun and Ciorba Ilie Marius and Puiac Ion Claudiu and Bancu Ligia Ariana},
title = {Correlations Between METAVIR Staging, the Viral Load and Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C, Before and after 12 Weeks of Antiviral Treatment},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2420-2424},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7353},
url = {https://revistadechimie.ro/Articles.asp?ID=7353}
}

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