Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania

Pop, Ovidiu Laurean; Pusta, Claudia Teodora Judea; Buhas, Camelia Liana; Judea, Adrian Sorin; Huniadi, Anca; Jurca, Claudia; Sandor, Mircea; Negrutiu, Bianca Maria; Buhas, Bogdan Adrian; Nikin, Zoran; Pascalau, Andrei

Ovidiu Laurean Pop, Claudia Teodora Judea Pusta, Camelia Liana Buhas, Adrian Sorin Judea, Anca Huniadi, Claudia Jurca, Mircea Sandor, Bianca Maria Negrutiu, Bogdan Adrian Buhas, Zoran Nikin, Andrei Pascalau

Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania

Abstract:

Lung cancer is the first cause of death worldwide of oncological patients. Most of them are non-small cell lung cancer (NSCLC) and many of them are characterized by different molecular markers that allow the development of personalized treatments. Epithelial growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are the most frequently tested genes in lung adenocarcinoma and other lung carcinomas with glandular component. The aim of our study is to evaluate the distribution of ALK gene mutation in lung cancer patient from North West part of Romania. We analysed a number of 289 lung biopsies along 18 months. The samples have been incubated with monoclonal ALK antibodies (clone D5F3), according to the manufacturer’s instruction. The interpretation guide provided by manufacturer was used to distinguish the positives vs negative cases. In our study from a total number of 289 lung biopsies, 196 cases were carcinomas. 57.65 % from the total number of lung cancers were adenocarcinomas. A total number of 79 cases have been analysed for ALK gene supra expression. 5.08 % of adenocarcinomas were positive for ALK, but the mean age for this population is higher comparing with the data from other studies.

Keywords:
lung cancer; IHC; ALK; supra expression; TKI inhibitors

Issue: 2019, Volume 70, Issue 7

Pages: 2690-2693

Publication date: 2019/8/15

https://doi.org/10.37358/RC.19.7.7407

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POP, O.L., PUSTA, C.T.J., BUHAS, C.L., JUDEA, A.S., HUNIADI, A., JURCA, C., SANDOR, M., NEGRUTIU, B.M., BUHAS, B.A., NIKIN, Z., PASCALAU, A., Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania, Rev. Chim., 70(7), 2019, 2690-2693.

Vancouver
Pop OL, Pusta CTJ, Buhas CL, Judea AS, Huniadi A, Jurca C, Sandor M, Negrutiu BM, Buhas BA, Nikin Z, Pascalau A. Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania. Rev. Chim.[internet]. 2019 Jul;70(7):2690-2693. Available from: https://doi.org/10.37358/RC.19.7.7407

APA 6th edition
Pop, O.L., Pusta, C.T.J., Buhas, C.L., Judea, A.S., Huniadi, A., Jurca, C.,... Pascalau, A. (2019). Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania. Revista de Chimie, 70(7), 2690-2693. https://doi.org/10.37358/RC.19.7.7407

Harvard
Pop, O.L., Pusta, C.T.J., Buhas, C.L., Judea, A.S., Huniadi, A., Jurca, C., Sandor, M., Negrutiu, B.M., Buhas, B.A., Nikin, Z., Pascalau, A. (2019). 'Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania', Revista de Chimie, 70(7), pp. 2690-2693. https://doi.org/10.37358/RC.19.7.7407

IEEE
O.L. Pop, C.T.J. Pusta, C.L. Buhas, A.S. Judea, A. Huniadi, C. Jurca, M. Sandor, B.M. Negrutiu, B.A. Buhas, Z. Nikin, A. Pascalau, "Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania". Revista de Chimie, vol. 70, no. 7, pp. 2690-2693, 2019. [online]. https://doi.org/10.37358/RC.19.7.7407

Text
Ovidiu Laurean Pop, Claudia Teodora Judea Pusta, Camelia Liana Buhas, Adrian Sorin Judea, Anca Huniadi, Claudia Jurca, Mircea Sandor, Bianca Maria Negrutiu, Bogdan Adrian Buhas, Zoran Nikin, Andrei Pascalau,
Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2690-2693,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7407.
(https://revistadechimie.ro/Articles.asp?ID=7407)
Keywords: lung cancer; IHC; ALK; supra expression; TKI inhibitors

RIS
TY - JOUR
T1 - Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania
A1 - Pop, Ovidiu Laurean
A2 - Pusta, Claudia Teodora Judea
A3 - Buhas, Camelia Liana
A4 - Judea, Adrian Sorin
A5 - Huniadi, Anca
A6 - Jurca, Claudia
A7 - Sandor, Mircea
A8 - Negrutiu, Bianca Maria
A9 - Buhas, Bogdan Adrian
A10 - Nikin, Zoran
A11 - Pascalau, Andrei
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2690
EP - 2693
UR - https://doi.org/10.37358/RC.19.7.7407
KW - lung cancer
KW - IHC
KW - ALK
KW - supra expression
KW - TKI inhibitors
ER -

BibTex
@article{RevCh2019P2690,
author = {Pop Ovidiu Laurean and Pusta Claudia Teodora Judea and Buhas Camelia Liana and Judea Adrian Sorin and Huniadi Anca and Jurca Claudia and Sandor Mircea and Negrutiu Bianca Maria and Buhas Bogdan Adrian and Nikin Zoran and Pascalau Andrei},
title = {Anaplastic Lymphoma Kinase (ALK) Overexpression in Lung Cancer Biopsies - An 18 month study in north western Romania},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2690-2693},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7407},
url = {https://revistadechimie.ro/Articles.asp?ID=7407}
}

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