ANCA ALEXANDRA GRIGORIE, RAMONA ADRIANA SCHENKER, MICHAEL SCHENKER GLIOBLASTOMA MULTIFORME WITH ATYPICAL APPEARANCE We present the case of a 68-year-old patient who is hospitalized in our clinic for cognitive and attention disorders, progressively progressing over the past three months. The neurological examination revealed, besides cognitive decline, a motor deficit in the right limbs, and mild swallowing disorders for liquids. Although both CT and MRI were performed, the images obtained from the investigations were inconclusive, raising differential diagnosis problems. The patient was subjected to additional investigations, but the diagnosis of certainty was established by performing sterotactic biopsy and histological examination. Although cerebral MRI is the investigation of choice in the diagnosis of glioblastoma, in our patient’s case, the diagnosis of certainty was determined by stereotactic biopsy and subsequent histological examination.