Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative

Mioc, Marius; Avram, Sorin; Bercean, Vasile; Porcarasu, Mihaela Balan; Soica, Codruta; Susan, Razvan; Kurunczi, Ludovic

Marius Mioc, Sorin Avram, Vasile Bercean, Mihaela Balan Porcarasu, Codruta Soica, Razvan Susan, Ludovic Kurunczi

Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative

Abstract:

Angiogenesis plays an important function in tumor proliferation, one of the main angiogenic promoters being the vascular endothelial growth factor (VEGF) which activates specific receptors, particularly VEGFR-2. Thus, VEGFR-2 has become an essential therapeutic target in the development of new antitumor drugs. 1,2,4-triazoles show a wide range of biological activities, including antitumor effect, which was documented by numerous reports. In the current study the selection of 5-mercapto-1,2,4-triazole structure (1H-3-styryl-5-benzylidenehydrazino-carbonyl-methylsulfanil-1,2,4-triazole, Tz3a.7) was conducted based on molecular docking that emphasized it as suitable ligand for VEGFR-2 and EGFR1 receptors. Compound Tz3a.7 was synthesized and physicochemically and biologically evaluated thus revealing a moderate antiproliferative activity against breast cancer cell line MDA-MB-231.

Keywords:
1;2;4-triazole; antiproliferative; angiogenesis; breast cancer; VEGFR-2; EGFR1

Issue: 2017, Volume 68, Issue 4

Pages: 745-747

Publication date: 2017/5/15

https://doi.org/10.37358/RC.17.4.5544

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIOC, M., AVRAM, S., BERCEAN, V., PORCARASU, M.B., SOICA, C., SUSAN, R., KURUNCZI, L., Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative, Rev. Chim., 68(4), 2017, 745-747.

Vancouver
Mioc M, Avram S, Bercean V, Porcarasu MB, Soica C, Susan R, Kurunczi L. Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative. Rev. Chim.[internet]. 2017 Apr;68(4):745-747. Available from: https://doi.org/10.37358/RC.17.4.5544

APA 6th edition
Mioc, M., Avram, S., Bercean, V., Porcarasu, M.B., Soica, C., Susan, R. & Kurunczi, L. (2017). Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative. Revista de Chimie, 68(4), 745-747. https://doi.org/10.37358/RC.17.4.5544

Harvard
Mioc, M., Avram, S., Bercean, V., Porcarasu, M.B., Soica, C., Susan, R., Kurunczi, L. (2017). 'Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative', Revista de Chimie, 68(4), pp. 745-747. https://doi.org/10.37358/RC.17.4.5544

IEEE
M. Mioc, S. Avram, V. Bercean, M.B. Porcarasu, C. Soica, R. Susan, L. Kurunczi, "Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative". Revista de Chimie, vol. 68, no. 4, pp. 745-747, 2017. [online]. https://doi.org/10.37358/RC.17.4.5544

Text
Marius Mioc, Sorin Avram, Vasile Bercean, Mihaela Balan Porcarasu, Codruta Soica, Razvan Susan, Ludovic Kurunczi,
Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative,
Revista de Chimie,
Volume 68, Issue 4,
2017,
Pages 745-747,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.4.5544.
(https://revistadechimie.ro/Articles.asp?ID=5544)
Keywords: 1;2;4-triazole; antiproliferative; angiogenesis; breast cancer; VEGFR-2; EGFR1

RIS
TY - JOUR
T1 - Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative
A1 - Mioc, Marius
A2 - Avram, Sorin
A3 - Bercean, Vasile
A4 - Porcarasu, Mihaela Balan
A5 - Soica, Codruta
A6 - Susan, Razvan
A7 - Kurunczi, Ludovic
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 4
SP - 745
EP - 747
UR - https://doi.org/10.37358/RC.17.4.5544
KW - 1
KW - 2
KW - 4-triazole
KW - antiproliferative
KW - angiogenesis
KW - breast cancer
KW - VEGFR-2
KW - EGFR1
ER -

BibTex
@article{RevCh2017P745,
author = {Mioc Marius and Avram Sorin and Bercean Vasile and Porcarasu Mihaela Balan and Soica Codruta and Susan Razvan and Kurunczi Ludovic},
title = {Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative},
journal = {Revista de Chimie},
volume = {68},
number = {4},
pages = {745-747},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.4.5544},
url = {https://revistadechimie.ro/Articles.asp?ID=5544}
}

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