Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy

Nitulescu, George Mihai; Iancu, George; Nitulescu, Georgiana; Iancu, Raluca Claudia; Bogdanici, Camelia; Vasile, Danut

George Mihai Nitulescu, George Iancu, Georgiana Nitulescu, Raluca Claudia Iancu, Camelia Bogdanici, Danut Vasile

Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy

Abstract:

Breast cancer research is a priority nowadays because of the high burden the disease represents for health systems worldwide. New agents are intensively researched to overcome breast cancer biology. Our aminopyrazole derivatives showed promising results when tested in vitro on breast cancer cell lines, by inhibiting protein kinase pathways. Anti-proliferative effect of pyrazole compounds on different breast cancer cell lines was heterogeneous. Further research is necessary to design the optimal structure in terms of high antitumor efficacy and good safety profile. Ophthalmologist control is very important for patients with breast cancer because treatment with some drugs reported side ocular effects: cataract, maculopathy (crystals or drusen or yellowish spots), retinal hemorrhages or dry.

Keywords:
aminopyrazole derivatives; Prediction of Activity Spectra for Substances (PASS); triple-negative breast cancer; protein kinases inhibitors

Issue: 2017, Volume 68, Issue 4

Pages: 754-757

Publication date: 2017/5/15

https://doi.org/10.37358/RC.17.4.5546

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NITULESCU, G.M., IANCU, G., NITULESCU, G., IANCU, R.C., BOGDANICI, C., VASILE, D., Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy, Rev. Chim., 68(4), 2017, 754-757.

Vancouver
Nitulescu GM, Iancu G, Nitulescu G, Iancu RC, Bogdanici C, Vasile D. Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy. Rev. Chim.[internet]. 2017 Apr;68(4):754-757. Available from: https://doi.org/10.37358/RC.17.4.5546

APA 6th edition
Nitulescu, G.M., Iancu, G., Nitulescu, G., Iancu, R.C., Bogdanici, C. & Vasile, D. (2017). Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy. Revista de Chimie, 68(4), 754-757. https://doi.org/10.37358/RC.17.4.5546

Harvard
Nitulescu, G.M., Iancu, G., Nitulescu, G., Iancu, R.C., Bogdanici, C., Vasile, D. (2017). 'Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy', Revista de Chimie, 68(4), pp. 754-757. https://doi.org/10.37358/RC.17.4.5546

IEEE
G.M. Nitulescu, G. Iancu, G. Nitulescu, R.C. Iancu, C. Bogdanici, D. Vasile, "Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy". Revista de Chimie, vol. 68, no. 4, pp. 754-757, 2017. [online]. https://doi.org/10.37358/RC.17.4.5546

Text
George Mihai Nitulescu, George Iancu, Georgiana Nitulescu, Raluca Claudia Iancu, Camelia Bogdanici, Danut Vasile,
Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy,
Revista de Chimie,
Volume 68, Issue 4,
2017,
Pages 754-757,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.4.5546.
(https://revistadechimie.ro/Articles.asp?ID=5546)
Keywords: aminopyrazole derivatives; Prediction of Activity Spectra for Substances (PASS); triple-negative breast cancer; protein kinases inhibitors

RIS
TY - JOUR
T1 - Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy
A1 - Nitulescu, George Mihai
A2 - Iancu, George
A3 - Nitulescu, Georgiana
A4 - Iancu, Raluca Claudia
A5 - Bogdanici, Camelia
A6 - Vasile, Danut
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 4
SP - 754
EP - 757
UR - https://doi.org/10.37358/RC.17.4.5546
KW - aminopyrazole derivatives
KW - Prediction of Activity Spectra for Substances (PASS)
KW - triple-negative breast cancer
KW - protein kinases inhibitors
ER -

BibTex
@article{RevCh2017P754,
author = {Nitulescu George Mihai and Iancu George and Nitulescu Georgiana and Iancu Raluca Claudia and Bogdanici Camelia and Vasile Danut},
title = {Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy},
journal = {Revista de Chimie},
volume = {68},
number = {4},
pages = {754-757},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.4.5546},
url = {https://revistadechimie.ro/Articles.asp?ID=5546}
}

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