Vascular Reactivity and Proinflammatory Cytokines in the Obese Children

Popescu, Laura Anca; Virgolici, Bogdana; Stefan, Daciana Costina Andrada; Lixandru, Daniela; Timnea, Olivia; Virgolici, Horia; Oraseanu, Dumitru; Sinescu, Crina; Mohora, Maria

Laura Anca Popescu, Bogdana Virgolici, Daciana Costina Andrada Stefan, Daniela Lixandru, Olivia Timnea, Horia Virgolici, Dumitru Oraseanu, Crina Sinescu, Maria Mohora

Vascular Reactivity and Proinflammatory Cytokines in the Obese Children

Abstract:

The aim of this study was to evaluate the relation between inflammatory markers and the preatherosclerotic marker - flow mediated dilation (FMD). Thirty obese children (10-16 years old) and twenty controls were involved. The plasma inflammatory markers: CRP, fibrinogen, leptin, TNF-a, IL-6 were measured. Ultrasounds were used for FMD measurement, chemiluminescence for monocyte respiratory burst (RB), ELISA for C peptide and spectrophotometry for usual parameters. In the obese children versus the lean ones, the FMD was lower (p[0.001), the plasma values for TNF-a were similar (1.68 pg/mL vs 1.54 pg/mL), while plasma IL-6 was increased (4.01 pg/mL vs. 2.02 pg/mL, p[0.05). These cytokines were negatively correlated with FMD (r=-0.42, p[0.05) and positively with RB (r=50, p[0.05). The FMD was negatively correlated (p[0.05) with the values for diastolic blood pressure (r = -0.47), waist circumference (r = -0.55), uric acid (r = -0.47) and atherosclerotic index (r = -0.37). In conclusion, in the obese children, inflammation, dyslipidaemia, blood pressure and oxidative stress act in a cluster reducing the elasticity of the vessel walls.

Keywords:
childhood obesity; FMD; inflammation

Issue: 2017, Volume 68, Issue 4

Pages: 758-762

Publication date: 2017/5/15

https://doi.org/10.37358/RC.17.4.5547

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POPESCU, L.A., VIRGOLICI, B., STEFAN, D.C.A., LIXANDRU, D., TIMNEA, O., VIRGOLICI, H., ORASEANU, D., SINESCU, C., MOHORA, M., Vascular Reactivity and Proinflammatory Cytokines in the Obese Children, Rev. Chim., 68(4), 2017, 758-762.

Vancouver
Popescu LA, Virgolici B, Stefan DCA, Lixandru D, Timnea O, Virgolici H, Oraseanu D, Sinescu C, Mohora M. Vascular Reactivity and Proinflammatory Cytokines in the Obese Children. Rev. Chim.[internet]. 2017 Apr;68(4):758-762. Available from: https://doi.org/10.37358/RC.17.4.5547

APA 6th edition
Popescu, L.A., Virgolici, B., Stefan, D.C.A., Lixandru, D., Timnea, O., Virgolici, H.,... Mohora, M. (2017). Vascular Reactivity and Proinflammatory Cytokines in the Obese Children. Revista de Chimie, 68(4), 758-762. https://doi.org/10.37358/RC.17.4.5547

Harvard
Popescu, L.A., Virgolici, B., Stefan, D.C.A., Lixandru, D., Timnea, O., Virgolici, H., Oraseanu, D., Sinescu, C., Mohora, M. (2017). 'Vascular Reactivity and Proinflammatory Cytokines in the Obese Children', Revista de Chimie, 68(4), pp. 758-762. https://doi.org/10.37358/RC.17.4.5547

IEEE
L.A. Popescu, B. Virgolici, D.C.A. Stefan, D. Lixandru, O. Timnea, H. Virgolici, D. Oraseanu, C. Sinescu, M. Mohora, "Vascular Reactivity and Proinflammatory Cytokines in the Obese Children". Revista de Chimie, vol. 68, no. 4, pp. 758-762, 2017. [online]. https://doi.org/10.37358/RC.17.4.5547

Text
Laura Anca Popescu, Bogdana Virgolici, Daciana Costina Andrada Stefan, Daniela Lixandru, Olivia Timnea, Horia Virgolici, Dumitru Oraseanu, Crina Sinescu, Maria Mohora,
Vascular Reactivity and Proinflammatory Cytokines in the Obese Children,
Revista de Chimie,
Volume 68, Issue 4,
2017,
Pages 758-762,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.4.5547.
(https://revistadechimie.ro/Articles.asp?ID=5547)
Keywords: childhood obesity; FMD; inflammation

RIS
TY - JOUR
T1 - Vascular Reactivity and Proinflammatory Cytokines in the Obese Children
A1 - Popescu, Laura Anca
A2 - Virgolici, Bogdana
A3 - Stefan, Daciana Costina Andrada
A4 - Lixandru, Daniela
A5 - Timnea, Olivia
A6 - Virgolici, Horia
A7 - Oraseanu, Dumitru
A8 - Sinescu, Crina
A9 - Mohora, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 4
SP - 758
EP - 762
UR - https://doi.org/10.37358/RC.17.4.5547
KW - childhood obesity
KW - FMD
KW - inflammation
ER -

BibTex
@article{RevCh2017P758,
author = {Popescu Laura Anca and Virgolici Bogdana and Stefan Daciana Costina Andrada and Lixandru Daniela and Timnea Olivia and Virgolici Horia and Oraseanu Dumitru and Sinescu Crina and Mohora Maria},
title = {Vascular Reactivity and Proinflammatory Cytokines in the Obese Children},
journal = {Revista de Chimie},
volume = {68},
number = {4},
pages = {758-762},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.4.5547},
url = {https://revistadechimie.ro/Articles.asp?ID=5547}
}

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