The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment

Hussein, Stela Mariana Al; Todoran, Nicoleta; Imre, Silvia; Hussein, Hussam Al; Zaera, Ana Melero; Hussein, Hamida Al; Dogaru, Maria Titica

Stela Mariana Al Hussein, Nicoleta Todoran, Silvia Imre, Hussam Al Hussein, Ana Melero Zaera, Hamida Al Hussein, Maria Titica Dogaru

The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment

Abstract:

Despite the fact that in mild-to moderate acne vulgaris the standard first-line therapy is the topical treatment with fixed combinations of antimicrobial agents and retinoids, the skin type and the skin barrier function should be taken into account when formulating a topical product. The aim of this study was the comparison of three new semisolid formulations developed for topical application by evaluation of their rheological behavior, as well as the evaluation of in vitro percutaneous diffusion through human epidermis membrane of the pharmaceutical ingredients. Clindamycin phosphate and adapalene were incorporated in three different topical bases, an HPLC method for the determination of their content in the new formulations being developed and validated. A higher concentration of drugs was released from the two gel systems (hydroxypropylmethylcellulose 2.5% -F1 and hydroxyethylcellulose 3% -F2) than from the oil-in-water cream (F3) at pH 7.4, whereas at pH 5.5 the drugs were released in higher amounts from the formulation F3. Following the rheological behavoir associated with the penetrability through the human epidermis membrane, our study results suggest that F1 and F2 could be appropriate in treating acne lesions in patients with oily skin and unaffected skin barrier function. In contrast, the oil-in-water cream (F3), due to its possible emolient effect and its higher penetrability at pH 5.5 than gel vehicles, may be indicated for patients with dry and sensitive skin associated with an altered skin barrier.

Keywords:
clindamycin phosphate; adapalene; glycolic acid; topical preparation; percutaneous diffusion

Issue: 2017, Volume 68, Issue 5

Pages: 937-943

Publication date: 2017/6/15

https://doi.org/10.37358/RC.17.5.5585

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HUSSEIN, S.M.A., TODORAN, N., IMRE, S., HUSSEIN, H.A., ZAERA, A.M., HUSSEIN, H.A., DOGARU, M.T., The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment, Rev. Chim., 68(5), 2017, 937-943.

Vancouver
Hussein SMA, Todoran N, Imre S, Hussein HA, Zaera AM, Hussein HA, Dogaru MT. The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment. Rev. Chim.[internet]. 2017 May;68(5):937-943. Available from: https://doi.org/10.37358/RC.17.5.5585

APA 6th edition
Hussein, S.M.A., Todoran, N., Imre, S., Hussein, H.A., Zaera, A.M., Hussein, H.A. & Dogaru, M.T. (2017). The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment. Revista de Chimie, 68(5), 937-943. https://doi.org/10.37358/RC.17.5.5585

Harvard
Hussein, S.M.A., Todoran, N., Imre, S., Hussein, H.A., Zaera, A.M., Hussein, H.A., Dogaru, M.T. (2017). 'The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment', Revista de Chimie, 68(5), pp. 937-943. https://doi.org/10.37358/RC.17.5.5585

IEEE
S.M.A. Hussein, N. Todoran, S. Imre, H.A. Hussein, A.M. Zaera, H.A. Hussein, M.T. Dogaru, "The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment". Revista de Chimie, vol. 68, no. 5, pp. 937-943, 2017. [online]. https://doi.org/10.37358/RC.17.5.5585

Text
Stela Mariana Al Hussein, Nicoleta Todoran, Silvia Imre, Hussam Al Hussein, Ana Melero Zaera, Hamida Al Hussein, Maria Titica Dogaru,
The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment,
Revista de Chimie,
Volume 68, Issue 5,
2017,
Pages 937-943,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.5.5585.
(https://revistadechimie.ro/Articles.asp?ID=5585)
Keywords: clindamycin phosphate; adapalene; glycolic acid; topical preparation; percutaneous diffusion

RIS
TY - JOUR
T1 - The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment
A1 - Hussein, Stela Mariana Al
A2 - Todoran, Nicoleta
A3 - Imre, Silvia
A4 - Hussein, Hussam Al
A5 - Zaera, Ana Melero
A6 - Hussein, Hamida Al
A7 - Dogaru, Maria Titica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 5
SP - 937
EP - 943
UR - https://doi.org/10.37358/RC.17.5.5585
KW - clindamycin phosphate
KW - adapalene
KW - glycolic acid
KW - topical preparation
KW - percutaneous diffusion
ER -

BibTex
@article{RevCh2017P937,
author = {Hussein Stela Mariana Al and Todoran Nicoleta and Imre Silvia and Hussein Hussam Al and Zaera Ana Melero and Hussein Hamida Al and Dogaru Maria Titica},
title = {The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment},
journal = {Revista de Chimie},
volume = {68},
number = {5},
pages = {937-943},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.5.5585},
url = {https://revistadechimie.ro/Articles.asp?ID=5585}
}

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