Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain

Mosoiu, Daniela; Sporis, Mariana; Stanculeanu, Dana Lucia; Toader, Elena; Poroch, Vladimir; Boanca, Mihaela; Simion, Laurentiu

Daniela Mosoiu, Mariana Sporis, Dana Lucia Stanculeanu, Elena Toader, Vladimir Poroch, Mihaela Boanca, Laurentiu Simion

Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain

Abstract:

The present study evaluates the use of methadone in patients with advanced cancer and moderately-severe pain under palliative care at home over a period of 5 years, from 1996 to 2000. We calculated the index for methadone dosage increase (as a percentage and value in milligrams). Of the 1,079 patients cared for, 247 (22.89%) received methadone treatment: 126 from the very beginning, average dose of 15 mg / day (5- 50), and in 121 patients treatment with methadone was initiated at a later moment during the period they were cared for (5- 40). The median period of time of methadone administration was 27 days (1-416), the median dose of methadone at the moment of treatment discontinuation being 20 mg (5-60). The main reason for methadone treatment discontinuation was impossibility of oral administration (49.8% in terminal stages, 7.3% presenting nausea, vomiting), and 62.3% showed no side effects. Dosage increase index was 0.33 mg, 2.33% respectively. Methadone has been used mainly as a potent first line opioid, and has been shown to be effective and safe.

Keywords:
methadone; pain; opioid; palliative care

Issue: 2017, Volume 68, Issue 5

Pages: 1051-1054

Publication date: 2017/6/15

https://doi.org/10.37358/RC.17.5.5609

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MOSOIU, D., SPORIS, M., STANCULEANU, D.L., TOADER, E., POROCH, V., BOANCA, M., SIMION, L., Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain, Rev. Chim., 68(5), 2017, 1051-1054.

Vancouver
Mosoiu D, Sporis M, Stanculeanu DL, Toader E, Poroch V, Boanca M, Simion L. Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain. Rev. Chim.[internet]. 2017 May;68(5):1051-1054. Available from: https://doi.org/10.37358/RC.17.5.5609

APA 6th edition
Mosoiu, D., Sporis, M., Stanculeanu, D.L., Toader, E., Poroch, V., Boanca, M. & Simion, L. (2017). Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain. Revista de Chimie, 68(5), 1051-1054. https://doi.org/10.37358/RC.17.5.5609

Harvard
Mosoiu, D., Sporis, M., Stanculeanu, D.L., Toader, E., Poroch, V., Boanca, M., Simion, L. (2017). 'Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain', Revista de Chimie, 68(5), pp. 1051-1054. https://doi.org/10.37358/RC.17.5.5609

IEEE
D. Mosoiu, M. Sporis, D.L. Stanculeanu, E. Toader, V. Poroch, M. Boanca, L. Simion, "Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain". Revista de Chimie, vol. 68, no. 5, pp. 1051-1054, 2017. [online]. https://doi.org/10.37358/RC.17.5.5609

Text
Daniela Mosoiu, Mariana Sporis, Dana Lucia Stanculeanu, Elena Toader, Vladimir Poroch, Mihaela Boanca, Laurentiu Simion,
Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain,
Revista de Chimie,
Volume 68, Issue 5,
2017,
Pages 1051-1054,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.5.5609.
(https://revistadechimie.ro/Articles.asp?ID=5609)
Keywords: methadone; pain; opioid; palliative care

RIS
TY - JOUR
T1 - Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain
A1 - Mosoiu, Daniela
A2 - Sporis, Mariana
A3 - Stanculeanu, Dana Lucia
A4 - Toader, Elena
A5 - Poroch, Vladimir
A6 - Boanca, Mihaela
A7 - Simion, Laurentiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 5
SP - 1051
EP - 1054
UR - https://doi.org/10.37358/RC.17.5.5609
KW - methadone
KW - pain
KW - opioid
KW - palliative care
ER -

BibTex
@article{RevCh2017P1051,
author = {Mosoiu Daniela and Sporis Mariana and Stanculeanu Dana Lucia and Toader Elena and Poroch Vladimir and Boanca Mihaela and Simion Laurentiu},
title = {Use of Methadone as First Line Strong Opioid for Moderate-Severe Pain},
journal = {Revista de Chimie},
volume = {68},
number = {5},
pages = {1051-1054},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.5.5609},
url = {https://revistadechimie.ro/Articles.asp?ID=5609}
}

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