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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 5, 1070-1072

https://doi.org/10.37358/RC.17.5.5613

Dan Navolan, Mirela Nicolov, Simona Vladareanu, Ioana Ciohat, Marius Craina, Miroslav Tomovic, Dragos Nemescu, Alina Onofriescu, Mihaela Craciunescu, Florin Birsasteanu

Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?

Abstract:

Screening of fetal aneuploidies in early pregnancy is a well-established method in the materno-fetal medicine. The aim of our study was to analyze if the medians recommended by the manufacturers are adequate to perform an accurate screening or if there is a need for own laboratory medians calculation in second trimester biochemical marker screening.Sera were collected between 14 wp and 22 wp from 3374 singleton pregnancies. We analyzed three second trimester biochemical markers (AFP, hCG and free Estriol) concentration in all pregnant women and in a subgroup of pregnant women in which gestational age was determined based on crown-rump length. Our results showed that for all biochemical markers the difference between the manufacturer and the own calculated median was lower than 10% excepting the hCG value in the group of pregnant women in which the gestational age was determined on basis of crown-rump-length. Our results show it is recommended to replace the values of the median for hCG measurement with the own laboratory calculated medians. This does not seem to be necessary in the case of AFP and free Estriol measurement.
Keywords:
second trimester; biochemical markers; median values; own laboratory audit

Issue: 2017, Volume 68, Issue 5
Pages: 1070-1072
Publication date: 2017/6/15
https://doi.org/10.37358/RC.17.5.5613
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
NAVOLAN, D., NICOLOV, M., VLADAREANU, S., CIOHAT, I., CRAINA, M., TOMOVIC, M., NEMESCU, D., ONOFRIESCU, A., CRACIUNESCU, M., BIRSASTEANU, F., Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?, Rev. Chim., 68(5), 2017, 1070-1072.

Vancouver
Navolan D, Nicolov M, Vladareanu S, Ciohat I, Craina M, Tomovic M, Nemescu D, Onofriescu A, Craciunescu M, Birsasteanu F. Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?. Rev. Chim.[internet]. 2017 May;68(5):1070-1072. Available from: https://doi.org/10.37358/RC.17.5.5613


APA 6th edition
Navolan, D., Nicolov, M., Vladareanu, S., Ciohat, I., Craina, M., Tomovic, M.,... Birsasteanu, F. (2017). Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?. Revista de Chimie, 68(5), 1070-1072. https://doi.org/10.37358/RC.17.5.5613


Harvard
Navolan, D., Nicolov, M., Vladareanu, S., Ciohat, I., Craina, M., Tomovic, M., Nemescu, D., Onofriescu, A., Craciunescu, M., Birsasteanu, F. (2017). 'Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?', Revista de Chimie, 68(5), pp. 1070-1072. https://doi.org/10.37358/RC.17.5.5613


IEEE
D. Navolan, M. Nicolov, S. Vladareanu, I. Ciohat, M. Craina, M. Tomovic, D. Nemescu, A. Onofriescu, M. Craciunescu, F. Birsasteanu, "Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?". Revista de Chimie, vol. 68, no. 5, pp. 1070-1072, 2017. [online]. https://doi.org/10.37358/RC.17.5.5613


Text
Dan Navolan, Mirela Nicolov, Simona Vladareanu, Ioana Ciohat, Marius Craina, Miroslav Tomovic, Dragos Nemescu, Alina Onofriescu, Mihaela Craciunescu, Florin Birsasteanu,
Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?,
Revista de Chimie,
Volume 68, Issue 5,
2017,
Pages 1070-1072,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.5.5613.
(https://revistadechimie.ro/Articles.asp?ID=5613)
Keywords: second trimester; biochemical markers; median values; own laboratory audit


RIS
TY - JOUR
T1 - Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?
A1 - Navolan, Dan
A2 - Nicolov, Mirela
A3 - Vladareanu, Simona
A4 - Ciohat, Ioana
A5 - Craina, Marius
A6 - Tomovic, Miroslav
A7 - Nemescu, Dragos
A8 - Onofriescu, Alina
A9 - Craciunescu, Mihaela
A10 - Birsasteanu, Florin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 5
SP - 1070
EP - 1072
UR - https://doi.org/10.37358/RC.17.5.5613
KW - second trimester
KW - biochemical markers
KW - median values
KW - own laboratory audit
ER -


BibTex
@article{RevCh2017P1070,
author = {Navolan Dan and Nicolov Mirela and Vladareanu Simona and Ciohat Ioana and Craina Marius and Tomovic Miroslav and Nemescu Dragos and Onofriescu Alina and Craciunescu Mihaela and Birsasteanu Florin},
title = {Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?},
journal = {Revista de Chimie},
volume = {68},
number = {5},
pages = {1070-1072},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.5.5613},
url = {https://revistadechimie.ro/Articles.asp?ID=5613}
}
 
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