The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients

Goidescu, Cerasela Mihaela; Farcas, Anca Daniela; Anton, Florin Petru; Simiti, Luminita Animarie Vida

Cerasela Mihaela Goidescu, Anca Daniela Farcas, Florin Petru Anton, Luminita Animarie Vida Simiti

The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients

Abstract:

Oxidative stress (OS) is increased in chronic diseases, including cardiovascular (CV), but there are few data on its effects on the heart and vessels. The isoprostanes (IsoP) are bioactive compounds, with 8-iso-PGF25a being the most representative in vivo marker of OS. They correlate with the severity of heart failure (HF), but because data regarding OS levels in different types of HF are scarce, our study was aimed to evaluate it by assessing the urinary levels of 8-iso-PGF2aand its correlations with various biomarkers and parameters. Our prospective study included 53 consecutive patients with HF secondary to ischemic heart disease or dilative cardiomyopathy, divided according to the type of HF (acute, chronic decompensated or chronic compensated HF). The control group included 13 hypertensive patients, effectively treated. They underwent clinical, laboratory - serum NT-proBNP, creatinine, uric acid, lipids, C reactive protein (CRP) and urinary 8-iso-PGF2a and echocardiographic assessment. HF patients, regardless the type of HF, had higher 8-iso-PGF2a than controls (267.32pg/µmol vs. 19.82pg/µmol, p[0.001). The IsoP level was directly correlated with ejection fraction (EF) (r=-0.31, p=0.01) and NT-proBNP level (r=0.29, p=0.019). The relative wall thickness (RWT) was negatively correlated with IsoP (r=-0.55, p[0.001). Also 8-iso-PGF25a was higher by 213.59pg/µmol in the eccentric left ventricular (LV) hypertrophy subgroup comparing with the concentric subgroup (p=0.014), and the subgroups with severe mitral regurgitation (MR) and moderate/severe pulmonary hypertension (PAH) had the highest 8-iso-PGF2a levels. Male sex, severe MR, moderate/severe PAH, high LV mass and low RWT values were predictive for high OS level in HF patients.Eccentric cardiac remodeling, MR severity and PAH severity are independent predictors of OS in HF patients.

Keywords:
oxidative stress; heart failure; isoprostanes; 8-iso-PGF2a ventricular remodeling; relative wall thickness

Issue: 2017, Volume 68, Issue 7

Pages: 1506-1511

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5705

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GOIDESCU, C.M., FARCAS, A.D., ANTON, F.P., SIMITI, L.A.V., The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients, Rev. Chim., 68(7), 2017, 1506-1511.

Vancouver
Goidescu CM, Farcas AD, Anton FP, Simiti LAV. The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients. Rev. Chim.[internet]. 2017 Jul;68(7):1506-1511. Available from: https://doi.org/10.37358/RC.17.7.5705

APA 6th edition
Goidescu, C.M., Farcas, A.D., Anton, F.P. & Simiti, L.A.V. (2017). The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients. Revista de Chimie, 68(7), 1506-1511. https://doi.org/10.37358/RC.17.7.5705

Harvard
Goidescu, C.M., Farcas, A.D., Anton, F.P., Simiti, L.A.V. (2017). 'The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients', Revista de Chimie, 68(7), pp. 1506-1511. https://doi.org/10.37358/RC.17.7.5705

IEEE
C.M. Goidescu, A.D. Farcas, F.P. Anton, L.A.V. Simiti, "The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients". Revista de Chimie, vol. 68, no. 7, pp. 1506-1511, 2017. [online]. https://doi.org/10.37358/RC.17.7.5705

Text
Cerasela Mihaela Goidescu, Anca Daniela Farcas, Florin Petru Anton, Luminita Animarie Vida Simiti,
The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1506-1511,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5705.
(https://revistadechimie.ro/Articles.asp?ID=5705)
Keywords: oxidative stress; heart failure; isoprostanes; 8-iso-PGF2a ventricular remodeling; relative wall thickness

RIS
TY - JOUR
T1 - The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients
A1 - Goidescu, Cerasela Mihaela
A2 - Farcas, Anca Daniela
A3 - Anton, Florin Petru
A4 - Simiti, Luminita Animarie Vida
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1506
EP - 1511
UR - https://doi.org/10.37358/RC.17.7.5705
KW - oxidative stress
KW - heart failure
KW - isoprostanes
KW - 8-iso-PGF2a ventricular remodeling
KW - relative wall thickness
ER -

BibTex
@article{RevCh2017P1506,
author = {Goidescu Cerasela Mihaela and Farcas Anca Daniela and Anton Florin Petru and Simiti Luminita Animarie Vida},
title = {The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1506-1511},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5705},
url = {https://revistadechimie.ro/Articles.asp?ID=5705}
}

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