Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?

Buruiana, Andra; Dumitru, Nicoleta; Ghemigian, Adina; Petrova, Eugenia Nedeltcheva

Andra Buruiana, Nicoleta Dumitru, Adina Ghemigian, Eugenia Nedeltcheva Petrova

Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?

Abstract:

Thyroid carcinoma is the most common endocrine cancer representing 1-1.5% of all cancers diagnosed annually. Differentiated thyroid carcinoma (DTC) with the 2 main subtypes, papillary (PTC) and follicular (FTC), is the most common. DTC incidence has increased significantly in recent years, mainly due to increased and early use of imaging techniques (thyroid ultrasonography) and fine needle biopsy of thyroid nodules. Although after radical treatment, DTC is considered to be curable, histologic and clinical presentation is very diverse, the recurrence rate being 10-30%, while 5% of patients are resistant to conventional therapy, and some are even incurable. In recent years, there has been progress in terms of describing genetic changes in thyroid carcinoma, genetic testing providing important information that may influence therapeutic decision. The practical importance of these genetic mutations (for example, BRAF V600E, RAS, etc.) and their roles in tumorigenesis, the clinical features, treatment and prognosis of thyroid carcinoma is still controversial and incompletely elucidated.The increase knowledge of molecular pathogenesis and tumorigenesis in thyroid cancer lead to the emergence of new therapies with targeted antitumor effect and minimal toxicity. Patient selection should be made taking into account the risk stratification and tangible benefits, molecular tests being expensive and inaccessible.

Keywords:
differentiated thyroid carcinoma; genetic mutations; BRAF V600E

Issue: 2017, Volume 68, Issue 7

Pages: 1557-1559

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5715

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BURUIANA, A., DUMITRU, N., GHEMIGIAN, A., PETROVA, E.N., Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?, Rev. Chim., 68(7), 2017, 1557-1559.

Vancouver
Buruiana A, Dumitru N, Ghemigian A, Petrova EN. Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?. Rev. Chim.[internet]. 2017 Jul;68(7):1557-1559. Available from: https://doi.org/10.37358/RC.17.7.5715

APA 6th edition
Buruiana, A., Dumitru, N., Ghemigian, A. & Petrova, E.N. (2017). Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?. Revista de Chimie, 68(7), 1557-1559. https://doi.org/10.37358/RC.17.7.5715

Harvard
Buruiana, A., Dumitru, N., Ghemigian, A., Petrova, E.N. (2017). 'Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?', Revista de Chimie, 68(7), pp. 1557-1559. https://doi.org/10.37358/RC.17.7.5715

IEEE
A. Buruiana, N. Dumitru, A. Ghemigian, E.N. Petrova, "Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?". Revista de Chimie, vol. 68, no. 7, pp. 1557-1559, 2017. [online]. https://doi.org/10.37358/RC.17.7.5715

Text
Andra Buruiana, Nicoleta Dumitru, Adina Ghemigian, Eugenia Nedeltcheva Petrova,
Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1557-1559,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5715.
(https://revistadechimie.ro/Articles.asp?ID=5715)
Keywords: differentiated thyroid carcinoma; genetic mutations; BRAF V600E

RIS
TY - JOUR
T1 - Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?
A1 - Buruiana, Andra
A2 - Dumitru, Nicoleta
A3 - Ghemigian, Adina
A4 - Petrova, Eugenia Nedeltcheva
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1557
EP - 1559
UR - https://doi.org/10.37358/RC.17.7.5715
KW - differentiated thyroid carcinoma
KW - genetic mutations
KW - BRAF V600E
ER -

BibTex
@article{RevCh2017P1557,
author = {Buruiana Andra and Dumitru Nicoleta and Ghemigian Adina and Petrova Eugenia Nedeltcheva},
title = {Genetic Testing in Differentiated Thyroid Carcinoma - Important or Not?},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1557-1559},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5715},
url = {https://revistadechimie.ro/Articles.asp?ID=5715}
}

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