Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome

Gavris, Claudia; Poroch, Vladimir; Simion, Laurentiu; Baracan, Adrian; Toader, Elena; Pascu, Alina Mihaela

Claudia Gavris, Vladimir Poroch, Laurentiu Simion, Adrian Baracan, Elena Toader, Alina Mihaela Pascu

Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome

Abstract:

The study aimed to test the inflammation hypothesis in antiphospholipid syndrome (APS) by assessing biochemical markers of inflammation and platelet activation. Forty one patients with APS were compared to 40 controls. High-sensitivity C-reactive protein (hs-CRP) (as inflammatory biomarker), P-selectin and soluble CD40L (sCD40L) (as platelet activation markers) were measured by ELISA at enrolment and after 12 months follow-up. Serum hs-CRP, P-selectin and sCD40L levels were significantly higher in patients with APS compared to controls. P-selectin was significantly higher in APS patients with recurrent or acute thrombosis compared to APS patients with no recurrent thrombotic events. Serum hs-CRP and anticardiolipin antibodies (aCL) and were independent predictors of thrombosis in APS. In conclusion, persistent increased hs-CRP titres demonstrated low-grade inflammation in APS. Serum biomarkers as aCL and hs-CRP were independent thrombotic cumulative risk predictors in patients with APS.

Keywords:
Antiphospholipid syndrome; biochemical markers; high-sensitivity C-reactive protein; P-selectin; soluble CD40L; anticardiolipin antibodies; recurrent thrombosis

Issue: 2017, Volume 68, Issue 7

Pages: 1586-1590

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5722

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GAVRIS, C., POROCH, V., SIMION, L., BARACAN, A., TOADER, E., PASCU, A.M., Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome, Rev. Chim., 68(7), 2017, 1586-1590.

Vancouver
Gavris C, Poroch V, Simion L, Baracan A, Toader E, Pascu AM. Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome. Rev. Chim.[internet]. 2017 Jul;68(7):1586-1590. Available from: https://doi.org/10.37358/RC.17.7.5722

APA 6th edition
Gavris, C., Poroch, V., Simion, L., Baracan, A., Toader, E. & Pascu, A.M. (2017). Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome. Revista de Chimie, 68(7), 1586-1590. https://doi.org/10.37358/RC.17.7.5722

Harvard
Gavris, C., Poroch, V., Simion, L., Baracan, A., Toader, E., Pascu, A.M. (2017). 'Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome', Revista de Chimie, 68(7), pp. 1586-1590. https://doi.org/10.37358/RC.17.7.5722

IEEE
C. Gavris, V. Poroch, L. Simion, A. Baracan, E. Toader, A.M. Pascu, "Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome". Revista de Chimie, vol. 68, no. 7, pp. 1586-1590, 2017. [online]. https://doi.org/10.37358/RC.17.7.5722

Text
Claudia Gavris, Vladimir Poroch, Laurentiu Simion, Adrian Baracan, Elena Toader, Alina Mihaela Pascu,
Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1586-1590,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5722.
(https://revistadechimie.ro/Articles.asp?ID=5722)
Keywords: Antiphospholipid syndrome; biochemical markers; high-sensitivity C-reactive protein; P-selectin; soluble CD40L; anticardiolipin antibodies; recurrent thrombosis

RIS
TY - JOUR
T1 - Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome
A1 - Gavris, Claudia
A2 - Poroch, Vladimir
A3 - Simion, Laurentiu
A4 - Baracan, Adrian
A5 - Toader, Elena
A6 - Pascu, Alina Mihaela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1586
EP - 1590
UR - https://doi.org/10.37358/RC.17.7.5722
KW - Antiphospholipid syndrome
KW - biochemical markers
KW - high-sensitivity C-reactive protein
KW - P-selectin
KW - soluble CD40L
KW - anticardiolipin antibodies
KW - recurrent thrombosis
ER -

BibTex
@article{RevCh2017P1586,
author = {Gavris Claudia and Poroch Vladimir and Simion Laurentiu and Baracan Adrian and Toader Elena and Pascu Alina Mihaela},
title = {Biochemical Markers with Low-grade Inflammation as Predictors of Thrombotic Events in Antiphospholipid Syndrome},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1586-1590},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5722},
url = {https://revistadechimie.ro/Articles.asp?ID=5722}
}

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