Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds

Tita, Ioana Cristina; Marian, Eleonora; Tita, Bogdan; Toma, Claudia Crina; Vicas, Laura

Ioana Cristina Tita, Eleonora Marian, Bogdan Tita, Claudia Crina Toma, Laura Vicas

Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds

Abstract:

Thermal analysis is one of the most frequently used instrumental techniques in the pharmaceutical research, for the thermal characterization of different materials from solids to semi-solids, which are of pharmaceutical relevance. In this paper, simultaneous thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC) were used for characterization of the thermal behaviour of candesartan cilexetil - active substance (C-AS) under dynamic nitrogen atmosphere and nonisothermal conditions, in comparison with pharmaceutical product containing the corresponding active substance. It was observed that the commercial samples showed a different thermal profile than the standard sample, caused by the presence of excipients in the pharmaceutical product and to possible interaction of these with the active substance. The Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) were used as complementary techniques adequately implement and assist in interpretation of the thermal results. The main conclusion of this comparative study was that the TG/DTG and DSC curves, together with the FT-IR spectra, respectively X-ray difractograms constitute believe data for the discrimination between the pure substance and pharmaceutical forms.

Keywords:
candesartan; active substance; pharmaceutical product; TG/DTG/DSC; FT-IR; X-ray

Issue: 2017, Volume 68, Issue 8

Pages: 1895-1902

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5787

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TITA, I.C., MARIAN, E., TITA, B., TOMA, C.C., VICAS, L., Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds, Rev. Chim., 68(8), 2017, 1895-1902.

Vancouver
Tita IC, Marian E, Tita B, Toma CC, Vicas L. Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds. Rev. Chim.[internet]. 2017 Aug;68(8):1895-1902. Available from: https://doi.org/10.37358/RC.17.8.5787

APA 6th edition
Tita, I.C., Marian, E., Tita, B., Toma, C.C. & Vicas, L. (2017). Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds. Revista de Chimie, 68(8), 1895-1902. https://doi.org/10.37358/RC.17.8.5787

Harvard
Tita, I.C., Marian, E., Tita, B., Toma, C.C., Vicas, L. (2017). 'Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds', Revista de Chimie, 68(8), pp. 1895-1902. https://doi.org/10.37358/RC.17.8.5787

IEEE
I.C. Tita, E. Marian, B. Tita, C.C. Toma, L. Vicas, "Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds". Revista de Chimie, vol. 68, no. 8, pp. 1895-1902, 2017. [online]. https://doi.org/10.37358/RC.17.8.5787

Text
Ioana Cristina Tita, Eleonora Marian, Bogdan Tita, Claudia Crina Toma, Laura Vicas,
Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1895-1902,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5787.
(https://revistadechimie.ro/Articles.asp?ID=5787)
Keywords: candesartan; active substance; pharmaceutical product; TG/DTG/DSC; FT-IR; X-ray

RIS
TY - JOUR
T1 - Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds
A1 - Tita, Ioana Cristina
A2 - Marian, Eleonora
A3 - Tita, Bogdan
A4 - Toma, Claudia Crina
A5 - Vicas, Laura
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1895
EP - 1902
UR - https://doi.org/10.37358/RC.17.8.5787
KW - candesartan
KW - active substance
KW - pharmaceutical product
KW - TG/DTG/DSC
KW - FT-IR
KW - X-ray
ER -

BibTex
@article{RevCh2017P1895,
author = {Tita Ioana Cristina and Marian Eleonora and Tita Bogdan and Toma Claudia Crina and Vicas Laura},
title = {Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1895-1902},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5787},
url = {https://revistadechimie.ro/Articles.asp?ID=5787}
}

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