Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression

Iftode, Andrada; Marti, Teodora Daniela; Voicu, Mirela; Simu, Sebastian; Heghes, Alina; Borcan, Florin; Motoc, Andrei

Andrada Iftode, Teodora Daniela Marti, Mirela Voicu, Sebastian Simu, Alina Heghes, Florin Borcan, Andrei Motoc

Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression

Abstract:

As we know today, cancer is a disease caused by the uncontrolled growth of a single cell. This development is triggered by mutations, changes in DNA that affect genes in such a way that they increase cancer cells. In the present study, an experimental model based on skin carcinoma xenograft mice was developed and tested. There were studied: the mice weight, the tumor volume, and the evolution of different skin parameters such as transepidermal water loss (TWL), erythema and the hydration level of stratum corneum; mice were divided in four groups: a control group, a group of mice injected with physiological saline solution, another one with immunosuppression, and a group of mice with immunosuppression and xenograft of A375 cells. The results indicate that administration of cyclophosphamide significantly reduced the number of neutrophils and lymphocytes and last two mice groups revealed more pronounced modifications of skin parameters compared to first two groups.

Keywords:
cyclophosphamide; erythema; skin carcinoma; stratum corneum; TWL

Issue: 2017, Volume 68, Issue 9

Pages: 2098-2101

Publication date: 2017/10/15

https://doi.org/10.37358/RC.17.9.5831

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IFTODE, A., MARTI, T.D., VOICU, M., SIMU, S., HEGHES, A., BORCAN, F., MOTOC, A., Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression, Rev. Chim., 68(9), 2017, 2098-2101.

Vancouver
Iftode A, Marti TD, Voicu M, Simu S, Heghes A, Borcan F, Motoc A. Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression. Rev. Chim.[internet]. 2017 Sep;68(9):2098-2101. Available from: https://doi.org/10.37358/RC.17.9.5831

APA 6th edition
Iftode, A., Marti, T.D., Voicu, M., Simu, S., Heghes, A., Borcan, F. & Motoc, A. (2017). Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression. Revista de Chimie, 68(9), 2098-2101. https://doi.org/10.37358/RC.17.9.5831

Harvard
Iftode, A., Marti, T.D., Voicu, M., Simu, S., Heghes, A., Borcan, F., Motoc, A. (2017). 'Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression', Revista de Chimie, 68(9), pp. 2098-2101. https://doi.org/10.37358/RC.17.9.5831

IEEE
A. Iftode, T.D. Marti, M. Voicu, S. Simu, A. Heghes, F. Borcan, A. Motoc, "Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression". Revista de Chimie, vol. 68, no. 9, pp. 2098-2101, 2017. [online]. https://doi.org/10.37358/RC.17.9.5831

Text
Andrada Iftode, Teodora Daniela Marti, Mirela Voicu, Sebastian Simu, Alina Heghes, Florin Borcan, Andrei Motoc,
Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression,
Revista de Chimie,
Volume 68, Issue 9,
2017,
Pages 2098-2101,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.9.5831.
(https://revistadechimie.ro/Articles.asp?ID=5831)
Keywords: cyclophosphamide; erythema; skin carcinoma; stratum corneum; TWL

RIS
TY - JOUR
T1 - Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression
A1 - Iftode, Andrada
A2 - Marti, Teodora Daniela
A3 - Voicu, Mirela
A4 - Simu, Sebastian
A5 - Heghes, Alina
A6 - Borcan, Florin
A7 - Motoc, Andrei
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 9
SP - 2098
EP - 2101
UR - https://doi.org/10.37358/RC.17.9.5831
KW - cyclophosphamide
KW - erythema
KW - skin carcinoma
KW - stratum corneum
KW - TWL
ER -

BibTex
@article{RevCh2017P2098,
author = {Iftode Andrada and Marti Teodora Daniela and Voicu Mirela and Simu Sebastian and Heghes Alina and Borcan Florin and Motoc Andrei},
title = {Evaluation of a Skin Carcinoma Xenograft Mice Model Supplemented by Chemical Immunosuppression},
journal = {Revista de Chimie},
volume = {68},
number = {9},
pages = {2098-2101},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.9.5831},
url = {https://revistadechimie.ro/Articles.asp?ID=5831}
}

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