Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia

Pinzariu, Alin Constantin; Pasca, Sorin Aurelian; Sindilar, Allia; Drochioi, Cristian; Balan, Mihail; Oboroceanu, Teodor; Niculescu, Simona; Crauciuc, Dragos Valentin; Crauciuc, Eduard Gabriel; Luca, Andrei; Butcovan, Doina; Sindilar, Eusebiu Viorel; Mocanu, Veronica

Alin Constantin Pinzariu, Sorin Aurelian Pasca, Allia Sindilar, Cristian Drochioi, Mihail Balan, Teodor Oboroceanu, Simona Niculescu, Dragos Valentin Crauciuc, Eduard Gabriel Crauciuc, Andrei Luca, Doina Butcovan, Eusebiu Viorel Sindilar, Veronica Mocanu

Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia

Abstract:

To examine the effect of high dose vitamin D3 treatment on visceral adipose tissue, we used vitamin D deficient male Wistar rats (18 months old) as a model of sarcopenia. The aging process is not only responsive for the losing muscle mass but also for redistribution of lipid resulting in altered fatty acid storage and dysdifferentiation of mesenchymal precursors. The effect of aging and vitamin D treatment (weekly oral gavage with 0.125 mg vitamin D3 (5000 IU)/100g body weight) on the omental adipose tissue were histological examinated. At the end of the experiment (9 monhs), adaptive changes to the reduction of adipogenesis and increased apoptosis in response to long-term treatment with vitamin D consisted of smaller size of adipocyte and moderate macrophage infiltrate.

Keywords:
vitamin D; sarcopenia; visceral adipose tissue; intramuscular fat; remodeling

Issue: 2017, Volume 68, Issue 9

Pages: 2139-2143

Publication date: 2017/10/15

https://doi.org/10.37358/RC.17.9.5842

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PINZARIU, A.C., PASCA, S.A., SINDILAR, A., DROCHIOI, C., BALAN, M., OBOROCEANU, T., NICULESCU, S., CRAUCIUC, D.V., CRAUCIUC, E.G., LUCA, A., BUTCOVAN, D., SINDILAR, E.V., MOCANU, V., Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia, Rev. Chim., 68(9), 2017, 2139-2143.

Vancouver
Pinzariu AC, Pasca SA, Sindilar A, Drochioi C, Balan M, Oboroceanu T, Niculescu S, Crauciuc DV, Crauciuc EG, Luca A, Butcovan D, Sindilar EV, Mocanu V. Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia. Rev. Chim.[internet]. 2017 Sep;68(9):2139-2143. Available from: https://doi.org/10.37358/RC.17.9.5842

APA 6th edition
Pinzariu, A.C., Pasca, S.A., Sindilar, A., Drochioi, C., Balan, M., Oboroceanu, T.,... Mocanu, V. (2017). Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia. Revista de Chimie, 68(9), 2139-2143. https://doi.org/10.37358/RC.17.9.5842

Harvard
Pinzariu, A.C., Pasca, S.A., Sindilar, A., Drochioi, C., Balan, M., Oboroceanu, T., Niculescu, S., Crauciuc, D.V., Crauciuc, E.G., Luca, A., Butcovan, D., Sindilar, E.V., Mocanu, V. (2017). 'Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia', Revista de Chimie, 68(9), pp. 2139-2143. https://doi.org/10.37358/RC.17.9.5842

IEEE
A.C. Pinzariu, S.A. Pasca, A. Sindilar, C. Drochioi, M. Balan, T. Oboroceanu, S. Niculescu, D.V. Crauciuc, E.G. Crauciuc, A. Luca, D. Butcovan, E.V. Sindilar, V. Mocanu, "Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia". Revista de Chimie, vol. 68, no. 9, pp. 2139-2143, 2017. [online]. https://doi.org/10.37358/RC.17.9.5842

Text
Alin Constantin Pinzariu, Sorin Aurelian Pasca, Allia Sindilar, Cristian Drochioi, Mihail Balan, Teodor Oboroceanu, Simona Niculescu, Dragos Valentin Crauciuc, Eduard Gabriel Crauciuc, Andrei Luca, Doina Butcovan, Eusebiu Viorel Sindilar, Veronica Mocanu,
Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia,
Revista de Chimie,
Volume 68, Issue 9,
2017,
Pages 2139-2143,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.9.5842.
(https://revistadechimie.ro/Articles.asp?ID=5842)
Keywords: vitamin D; sarcopenia; visceral adipose tissue; intramuscular fat; remodeling

RIS
TY - JOUR
T1 - Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia
A1 - Pinzariu, Alin Constantin
A2 - Pasca, Sorin Aurelian
A3 - Sindilar, Allia
A4 - Drochioi, Cristian
A5 - Balan, Mihail
A6 - Oboroceanu, Teodor
A7 - Niculescu, Simona
A8 - Crauciuc, Dragos Valentin
A9 - Crauciuc, Eduard Gabriel
A10 - Luca, Andrei
A11 - Butcovan, Doina
A12 - Sindilar, Eusebiu Viorel
A13 - Mocanu, Veronica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 9
SP - 2139
EP - 2143
UR - https://doi.org/10.37358/RC.17.9.5842
KW - vitamin D
KW - sarcopenia
KW - visceral adipose tissue
KW - intramuscular fat
KW - remodeling
ER -

BibTex
@article{RevCh2017P2139,
author = {Pinzariu Alin Constantin and Pasca Sorin Aurelian and Sindilar Allia and Drochioi Cristian and Balan Mihail and Oboroceanu Teodor and Niculescu Simona and Crauciuc Dragos Valentin and Crauciuc Eduard Gabriel and Luca Andrei and Butcovan Doina and Sindilar Eusebiu Viorel and Mocanu Veronica},
title = {Adipose Tissue Remodeling by Prolonged Administration of High Dose of Vitamin D3 in Rats Treated to Prevent Sarcopenia},
journal = {Revista de Chimie},
volume = {68},
number = {9},
pages = {2139-2143},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.9.5842},
url = {https://revistadechimie.ro/Articles.asp?ID=5842}
}

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