Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS

Nicolescu, Cristian Mircea; Bedreag, Ovidiu; Osakwe, Henry; Pop, Alexandru; Nicolescu, Laura Corina

Cristian Mircea Nicolescu, Ovidiu Bedreag, Henry Osakwe, Alexandru Pop, Laura Corina Nicolescu

Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS

Abstract:

Hypoalbuminemia occurs in about 90% of critically ill patients admitted in the intensive care unit (ICU), this is caused by an increase in microvascular permeability (capillary and venous wall) as a result of systemic inflammatory reaction (SIRS) and decreased synthesis of hepatic albumin in acute liver response. The aim of this study is to determine the incidence of hypoalbuminaemia in patients with non-septic SIRS (induced by surgical trauma or multiple trauma) and to assess the plasma albumin level as a potential biomarker of severity in the prognosis of these patients. The albumin plasma level of ICU admitted patients were determined every 24h and 48h, patients were continuously monitored for complications. Hypoalbuminemia is probably the cause of prolonged ileus, gastroparesis, sepsis, fistula and acute renal failure). The statistical processing of data consisted in compiling descriptive statistics on values of albumin, highlighting the albumin-age relationship by the regression method. Calculation of mean plasma albumin values for groups of patients without clinical complications, those with clinical complications or with complications and who died and performing the Scheffe( multiple comparison test), correlation tests between albumin value at 48h and APACHE II score (prediction score Of the critical patient) as well as a descriptive analysis taking into account the 3 g / dl albumin value (factor that differentiates mild to moderate hypoalbuminemia in clinical practice) and performing the non-parametric Chi-Square test for validation of statistical analysis.

Keywords:
Hypoalbuminemia; Apache II score; sepsis; prolonged ileus; prolonged gastroparesis; sepsis

Issue: 2017, Volume 68, Issue 9

Pages: 2181-2188

Publication date: 2017/10/15

https://doi.org/10.37358/RC.17.9.5852

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NICOLESCU, C.M., BEDREAG, O., OSAKWE, H., POP, A., NICOLESCU, L.C., Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS, Rev. Chim., 68(9), 2017, 2181-2188.

Vancouver
Nicolescu CM, Bedreag O, Osakwe H, Pop A, Nicolescu LC. Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS. Rev. Chim.[internet]. 2017 Sep;68(9):2181-2188. Available from: https://doi.org/10.37358/RC.17.9.5852

APA 6th edition
Nicolescu, C.M., Bedreag, O., Osakwe, H., Pop, A. & Nicolescu, L.C. (2017). Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS. Revista de Chimie, 68(9), 2181-2188. https://doi.org/10.37358/RC.17.9.5852

Harvard
Nicolescu, C.M., Bedreag, O., Osakwe, H., Pop, A., Nicolescu, L.C. (2017). 'Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS', Revista de Chimie, 68(9), pp. 2181-2188. https://doi.org/10.37358/RC.17.9.5852

IEEE
C.M. Nicolescu, O. Bedreag, H. Osakwe, A. Pop, L.C. Nicolescu, "Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS". Revista de Chimie, vol. 68, no. 9, pp. 2181-2188, 2017. [online]. https://doi.org/10.37358/RC.17.9.5852

Text
Cristian Mircea Nicolescu, Ovidiu Bedreag, Henry Osakwe, Alexandru Pop, Laura Corina Nicolescu,
Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS,
Revista de Chimie,
Volume 68, Issue 9,
2017,
Pages 2181-2188,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.9.5852.
(https://revistadechimie.ro/Articles.asp?ID=5852)
Keywords: Hypoalbuminemia; Apache II score; sepsis; prolonged ileus; prolonged gastroparesis; sepsis

RIS
TY - JOUR
T1 - Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS
A1 - Nicolescu, Cristian Mircea
A2 - Bedreag, Ovidiu
A3 - Osakwe, Henry
A4 - Pop, Alexandru
A5 - Nicolescu, Laura Corina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 9
SP - 2181
EP - 2188
UR - https://doi.org/10.37358/RC.17.9.5852
KW - Hypoalbuminemia
KW - Apache II score
KW - sepsis
KW - prolonged ileus
KW - prolonged gastroparesis
KW - sepsis
ER -

BibTex
@article{RevCh2017P2181,
author = {Nicolescu Cristian Mircea and Bedreag Ovidiu and Osakwe Henry and Pop Alexandru and Nicolescu Laura Corina},
title = {Evaluation of Plasma Albumin as a Potential Prognostic Biomarker in Patients with Traumatic SIRS},
journal = {Revista de Chimie},
volume = {68},
number = {9},
pages = {2181-2188},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.9.5852},
url = {https://revistadechimie.ro/Articles.asp?ID=5852}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)