Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide

Mihalache, Madalina; Oprea, Ovidiu; Guran, Cornelia; Ardelean, Ioana Lavinia

Madalina Mihalache, Ovidiu Oprea, Cornelia Guran, Ioana Lavinia Ardelean

Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide

Abstract:

This paper presents the synthesis and characterization of three complexes of Mn (II,III), with the a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) as ligands. The complexes corresponding formulas are: [Mn(TB)2(H2A)]Cl2 . 0.5C2H5OH (C1), [Mn2(TB)(A)(H2A)2(H2O)2(NO3)2](NO3)2. C2H5OH (C2) and [Mn2(TB)(A)(H2A)2(H2O)2(CH3COO)2](CH3COO)2 . 3H2O (C3), where A is H2A without 2 protons. C1-C3 compounds were characterized by standard physico-chemical methods: chemical elemental analysis, IR spectroscopy, UV-Vis-NIR spectroscopy, molar conductivity and thermal analysis. For the obtained C1-C3 complexes, but also for the ligands (H2A and TB) was tested the antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 and antitumor activity on HeLa tumour cells. It has been observed a moderate cytotoxic effect of the complexes C1-C3 on growth and metabolic activity of HeLa cells, while the ligands show a very weak effect on them. The obtained complexes inhibits the adhesion on the substrate of bacterial strains Staphylococcus aureus and Pseudomona aeruginosa, which recommends them for possible therapeutic applications.

Keywords:
alfa-ketoglutaric acid; 1-(o-tolyl) biguanide; manganese complexes; biological activity

Issue: 2017, Volume 68, Issue 10

Pages: 2209-2214

Publication date: 2017/11/15

https://doi.org/10.37358/RC.17.10.5857

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Citation Styles

Cite this article as:
MIHALACHE, M., OPREA, O., GURAN, C., ARDELEAN, I.L., Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide, Rev. Chim., 68(10), 2017, 2209-2214.

Vancouver
Mihalache M, Oprea O, Guran C, Ardelean IL. Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide. Rev. Chim.[internet]. 2017 Oct;68(10):2209-2214. Available from: https://doi.org/10.37358/RC.17.10.5857

APA 6th edition
Mihalache, M., Oprea, O., Guran, C. & Ardelean, I.L. (2017). Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide. Revista de Chimie, 68(10), 2209-2214. https://doi.org/10.37358/RC.17.10.5857

Harvard
Mihalache, M., Oprea, O., Guran, C., Ardelean, I.L. (2017). 'Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide', Revista de Chimie, 68(10), pp. 2209-2214. https://doi.org/10.37358/RC.17.10.5857

IEEE
M. Mihalache, O. Oprea, C. Guran, I.L. Ardelean, "Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide". Revista de Chimie, vol. 68, no. 10, pp. 2209-2214, 2017. [online]. https://doi.org/10.37358/RC.17.10.5857

Text
Madalina Mihalache, Ovidiu Oprea, Cornelia Guran, Ioana Lavinia Ardelean,
Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide,
Revista de Chimie,
Volume 68, Issue 10,
2017,
Pages 2209-2214,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.10.5857.
(https://revistadechimie.ro/Articles.asp?ID=5857)
Keywords: alfa-ketoglutaric acid; 1-(o-tolyl) biguanide; manganese complexes; biological activity

RIS
TY - JOUR
T1 - Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide
A1 - Mihalache, Madalina
A2 - Oprea, Ovidiu
A3 - Guran, Cornelia
A4 - Ardelean, Ioana Lavinia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 10
SP - 2209
EP - 2214
UR - https://doi.org/10.37358/RC.17.10.5857
KW - alfa-ketoglutaric acid
KW - 1-(o-tolyl) biguanide
KW - manganese complexes
KW - biological activity
ER -

BibTex
@article{RevCh2017P2209,
author = {Mihalache Madalina and Oprea Ovidiu and Guran Cornelia and Ardelean Ioana Lavinia},
title = {Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide},
journal = {Revista de Chimie},
volume = {68},
number = {10},
pages = {2209-2214},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.10.5857},
url = {https://revistadechimie.ro/Articles.asp?ID=5857}
}

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