The Effect on Health of Some Cardiovascular Risk Factors

Balint, Germaine Savoiu; Andoni, Mihaiela; Popovici, Ramona Amina; Rusu, Laura Cristina; Citu, Ioana; Rumel, Ramona Camelia; Ciobanu, Virgil

Germaine Savoiu Balint, Mihaiela Andoni, Ramona Amina Popovici, Laura Cristina Rusu, Ioana Citu, Ramona Camelia Rumel, Virgil Ciobanu

The Effect on Health of Some Cardiovascular Risk Factors

Abstract:

Arterial endothelium produces a large ramge of active factors which are indispensable for modulation of vasomotor tone and maintenance of vascular wall integrity. From these factors, nitric oxide (NO), wich is released by the endothelial cells as a response to acetylcholine or adenosine action on specific receptors, plays an important role.NO is the result of oxidation process of L-arginine into L-citrulline, under the action of endothelial nitric oxide synthase (NOSe), wich is activated by intracelluar Ca2+ - calmodulin complex . Our study, performed in isolated organ bath, analyzed vascular reactivity of 12 guinea pigs’ thoracic aorta rings. After phenylephrine -PHE 10-5 mol/L precontraction, the dose-effect curves for acetylcoline - ACH, adenosine 5’ phosphate - 5’ADP and sodium nitroprusside - SNP were determined, before and after incubation of preparation, for 1 hour, with 5% hydrosoluble cigarettes smoke extract (CSE). Statistic analysis, performed with the use of t pair test and ANOVA parametric test, showed that incubation of vascular preparation with 5% CSE has increased the contractile response to PHE 10-5 mol/L (p[0.05), has reduced the endothelium-dependent relaxing response to ATP 10-5 mol/L (p[0.001) and 5’ADP 10-5 molo/L (p[0.001), but has not significantly modified the endothelium-independent relaxing response to SNP 10-5 mol/L (p=0.05). As a conclusion, vascular rings incubation with 5% CSE induced a decrease of endothelium NO synthesis under the action of AXH and 5’ADP, but did not change the smooth muscle fiber respomse in the presence of NO released by SNP.

Keywords:
Arterial endothelium; acetylcholine; adenosine; L-arginine; L-citrulline; NOSe; phenylephrine

Issue: 2017, Volume 68, Issue 10

Pages: 2237-2242

Publication date: 2017/11/15

https://doi.org/10.37358/RC.17.10.5863

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BALINT, G.S., ANDONI, M., POPOVICI, R.A., RUSU, L.C., CITU, I., RUMEL, R.C., CIOBANU, V., The Effect on Health of Some Cardiovascular Risk Factors, Rev. Chim., 68(10), 2017, 2237-2242.

Vancouver
Balint GS, Andoni M, Popovici RA, Rusu LC, Citu I, Rumel RC, Ciobanu V. The Effect on Health of Some Cardiovascular Risk Factors. Rev. Chim.[internet]. 2017 Oct;68(10):2237-2242. Available from: https://doi.org/10.37358/RC.17.10.5863

APA 6th edition
Balint, G.S., Andoni, M., Popovici, R.A., Rusu, L.C., Citu, I., Rumel, R.C. & Ciobanu, V. (2017). The Effect on Health of Some Cardiovascular Risk Factors. Revista de Chimie, 68(10), 2237-2242. https://doi.org/10.37358/RC.17.10.5863

Harvard
Balint, G.S., Andoni, M., Popovici, R.A., Rusu, L.C., Citu, I., Rumel, R.C., Ciobanu, V. (2017). 'The Effect on Health of Some Cardiovascular Risk Factors', Revista de Chimie, 68(10), pp. 2237-2242. https://doi.org/10.37358/RC.17.10.5863

IEEE
G.S. Balint, M. Andoni, R.A. Popovici, L.C. Rusu, I. Citu, R.C. Rumel, V. Ciobanu, "The Effect on Health of Some Cardiovascular Risk Factors". Revista de Chimie, vol. 68, no. 10, pp. 2237-2242, 2017. [online]. https://doi.org/10.37358/RC.17.10.5863

Text
Germaine Savoiu Balint, Mihaiela Andoni, Ramona Amina Popovici, Laura Cristina Rusu, Ioana Citu, Ramona Camelia Rumel, Virgil Ciobanu,
The Effect on Health of Some Cardiovascular Risk Factors,
Revista de Chimie,
Volume 68, Issue 10,
2017,
Pages 2237-2242,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.10.5863.
(https://revistadechimie.ro/Articles.asp?ID=5863)
Keywords: Arterial endothelium; acetylcholine; adenosine; L-arginine; L-citrulline; NOSe; phenylephrine

RIS
TY - JOUR
T1 - The Effect on Health of Some Cardiovascular Risk Factors
A1 - Balint, Germaine Savoiu
A2 - Andoni, Mihaiela
A3 - Popovici, Ramona Amina
A4 - Rusu, Laura Cristina
A5 - Citu, Ioana
A6 - Rumel, Ramona Camelia
A7 - Ciobanu, Virgil
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 10
SP - 2237
EP - 2242
UR - https://doi.org/10.37358/RC.17.10.5863
KW - Arterial endothelium
KW - acetylcholine
KW - adenosine
KW - L-arginine
KW - L-citrulline
KW - NOSe
KW - phenylephrine
ER -

BibTex
@article{RevCh2017P2237,
author = {Balint Germaine Savoiu and Andoni Mihaiela and Popovici Ramona Amina and Rusu Laura Cristina and Citu Ioana and Rumel Ramona Camelia and Ciobanu Virgil},
title = {The Effect on Health of Some Cardiovascular Risk Factors},
journal = {Revista de Chimie},
volume = {68},
number = {10},
pages = {2237-2242},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.10.5863},
url = {https://revistadechimie.ro/Articles.asp?ID=5863}
}

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