Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells

Tatarciuc, Diana; Gentimir, Carmen; Zaharia, Catalina Anda; Costin, Andreea; Chelaru, Liliana; Cazan, Ionut; Stoleriu, Gabriela; Costuleanu, Marcel

Diana Tatarciuc, Carmen Gentimir, Catalina Anda Zaharia, Andreea Costin, Liliana Chelaru, Ionut Cazan, Gabriela Stoleriu, Marcel Costuleanu

Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells

Abstract:

Angiotensin II, angiotensin receptors, apelins and recently de-orphanized APJ receptors are important control factors of cardiovascular system. The present studies aimed the effects of apelin-13 and [Pyr1]-apelin-13 on apoptosis of cultured rat vascular smooth muscle cells, induced by enhanced concentrations of angiotensin II, in the presence of losartan, a specific inhibitor of AT1 angiotensin receptors type. The obtained data demonstrated that apelin-13 was less efficient in preventing the apoptosis of aortic smooth muscle cells in culture, induced by angiotensin II (in the presence of losartan), as compared to [Pyr1]-apelin-13. It could be concluded that the apoptotic effects induced by angiotensin II in rat aortic could be related to the involvement of AT2 angiotensin receptor type, other types of receptors or pathways unrelated to angiotensin receptors. Furthermore, the apoptotic effects induced by angiotensin II are counteracted by apelins in a structure-related manner.

Keywords:
angiotensin II; apelin-13; -apelin-13; rat aortic smooth muscle cells; apoptosis

Issue: 2017, Volume 68, Issue 10

Pages: 2431-2435

Publication date: 2017/11/15

https://doi.org/10.37358/RC.17.10.5899

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TATARCIUC, D., GENTIMIR, C., ZAHARIA, C.A., COSTIN, A., CHELARU, L., CAZAN, I., STOLERIU, G., COSTULEANU, M., Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells, Rev. Chim., 68(10), 2017, 2431-2435.

Vancouver
Tatarciuc D, Gentimir C, Zaharia CA, Costin A, Chelaru L, Cazan I, Stoleriu G, Costuleanu M. Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells. Rev. Chim.[internet]. 2017 Oct;68(10):2431-2435. Available from: https://doi.org/10.37358/RC.17.10.5899

APA 6th edition
Tatarciuc, D., Gentimir, C., Zaharia, C.A., Costin, A., Chelaru, L., Cazan, I., Stoleriu, G. & Costuleanu, M. (2017). Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells. Revista de Chimie, 68(10), 2431-2435. https://doi.org/10.37358/RC.17.10.5899

Harvard
Tatarciuc, D., Gentimir, C., Zaharia, C.A., Costin, A., Chelaru, L., Cazan, I., Stoleriu, G., Costuleanu, M. (2017). 'Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells', Revista de Chimie, 68(10), pp. 2431-2435. https://doi.org/10.37358/RC.17.10.5899

IEEE
D. Tatarciuc, C. Gentimir, C.A. Zaharia, A. Costin, L. Chelaru, I. Cazan, G. Stoleriu, M. Costuleanu, "Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells". Revista de Chimie, vol. 68, no. 10, pp. 2431-2435, 2017. [online]. https://doi.org/10.37358/RC.17.10.5899

Text
Diana Tatarciuc, Carmen Gentimir, Catalina Anda Zaharia, Andreea Costin, Liliana Chelaru, Ionut Cazan, Gabriela Stoleriu, Marcel Costuleanu,
Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells,
Revista de Chimie,
Volume 68, Issue 10,
2017,
Pages 2431-2435,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.10.5899.
(https://revistadechimie.ro/Articles.asp?ID=5899)
Keywords: angiotensin II; apelin-13; -apelin-13; rat aortic smooth muscle cells; apoptosis

RIS
TY - JOUR
T1 - Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells
A1 - Tatarciuc, Diana
A2 - Gentimir, Carmen
A3 - Zaharia, Catalina Anda
A4 - Costin, Andreea
A5 - Chelaru, Liliana
A6 - Cazan, Ionut
A7 - Stoleriu, Gabriela
A8 - Costuleanu, Marcel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 10
SP - 2431
EP - 2435
UR - https://doi.org/10.37358/RC.17.10.5899
KW - angiotensin II
KW - apelin-13
KW - -apelin-13
KW - rat aortic smooth muscle cells
KW - apoptosis
ER -

BibTex
@article{RevCh2017P2431,
author = {Tatarciuc Diana and Gentimir Carmen and Zaharia Catalina Anda and Costin Andreea and Chelaru Liliana and Cazan Ionut and Stoleriu Gabriela and Costuleanu Marcel},
title = {Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells},
journal = {Revista de Chimie},
volume = {68},
number = {10},
pages = {2431-2435},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.10.5899},
url = {https://revistadechimie.ro/Articles.asp?ID=5899}
}

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