Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing

Nitipir, Cornelia; Marin, Stefania; Marin, Maria Minodora; Kaya, Madalina Albu; Ghica, Mihaela Violeta; Mederle, Narcisa

Cornelia Nitipir, Stefania Marin, Maria Minodora Marin, Madalina Albu Kaya, Mihaela Violeta Ghica, Narcisa Mederle

Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing

Abstract:

Fire and burns represent the fourth cause of death in the world. Numerous options for dressings exist, but their selection should be based on several factors such as burn severity, wound location and water retention. Collagen (COLL) is the most common protein in the human body and, due to its biocompatibility, is the main component in biomaterials development. Mefenamic acid (MA) is a non-steroidal anti-inflammatory drug with analgesic properties, and carboxymethylcellulose (NaCMC) is a biocompatible and biodegradable polymer that is commonly used in biomedical field. Collagen - carboxymethylcellulose - mefenamic acid hydrogels, developed in order to be used in burn treatments were lyophilized and the corresponding spongious matrices were investigated by optical microscopy, FT-IR spectroscopy, water absorption, enzymatic degradation and drug release kinetics studies. All tests revealed proper morphological structure, favourable release patterns, convenient swelling capacity and degradation profiles, indicating the possibility of their use for medical applications.

Keywords:
collagen; mefenamic acid; carboxymethylcellulose; spongious matrices

Issue: 2017, Volume 68, Issue 11

Pages: 2605-2609

Publication date: 2017/12/15

https://doi.org/10.37358/RC.17.11.5938

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NITIPIR, C., MARIN, S., MARIN, M.M., KAYA, M.A., GHICA, M.V., MEDERLE, N., Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing, Rev. Chim., 68(11), 2017, 2605-2609.

Vancouver
Nitipir C, Marin S, Marin MM, Kaya MA, Ghica MV, Mederle N. Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing. Rev. Chim.[internet]. 2017 Nov;68(11):2605-2609. Available from: https://doi.org/10.37358/RC.17.11.5938

APA 6th edition
Nitipir, C., Marin, S., Marin, M.M., Kaya, M.A., Ghica, M.V. & Mederle, N. (2017). Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing. Revista de Chimie, 68(11), 2605-2609. https://doi.org/10.37358/RC.17.11.5938

Harvard
Nitipir, C., Marin, S., Marin, M.M., Kaya, M.A., Ghica, M.V., Mederle, N. (2017). 'Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing', Revista de Chimie, 68(11), pp. 2605-2609. https://doi.org/10.37358/RC.17.11.5938

IEEE
C. Nitipir, S. Marin, M.M. Marin, M.A. Kaya, M.V. Ghica, N. Mederle, "Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing". Revista de Chimie, vol. 68, no. 11, pp. 2605-2609, 2017. [online]. https://doi.org/10.37358/RC.17.11.5938

Text
Cornelia Nitipir, Stefania Marin, Maria Minodora Marin, Madalina Albu Kaya, Mihaela Violeta Ghica, Narcisa Mederle,
Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing,
Revista de Chimie,
Volume 68, Issue 11,
2017,
Pages 2605-2609,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.11.5938.
(https://revistadechimie.ro/Articles.asp?ID=5938)
Keywords: collagen; mefenamic acid; carboxymethylcellulose; spongious matrices

RIS
TY - JOUR
T1 - Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing
A1 - Nitipir, Cornelia
A2 - Marin, Stefania
A3 - Marin, Maria Minodora
A4 - Kaya, Madalina Albu
A5 - Ghica, Mihaela Violeta
A6 - Mederle, Narcisa
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 11
SP - 2605
EP - 2609
UR - https://doi.org/10.37358/RC.17.11.5938
KW - collagen
KW - mefenamic acid
KW - carboxymethylcellulose
KW - spongious matrices
ER -

BibTex
@article{RevCh2017P2605,
author = {Nitipir Cornelia and Marin Stefania and Marin Maria Minodora and Kaya Madalina Albu and Ghica Mihaela Violeta and Mederle Narcisa},
title = {Hybrid Collagen-NaCMC Matrices Loaded with Mefenamic Acid for Wound Healing},
journal = {Revista de Chimie},
volume = {68},
number = {11},
pages = {2605-2609},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.11.5938},
url = {https://revistadechimie.ro/Articles.asp?ID=5938}
}

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