Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?

Costache, Irina Iuliana; Mitu, Florin; Namat, Razan Al; Ivanov, Iuliu; Popescu, Roxana; Mitu, Ovidiu; Costache, Alexandru Dan; Aprotosoaie, Ana Clara

Irina Iuliana Costache, Florin Mitu, Razan Al Namat, Iuliu Ivanov, Roxana Popescu, Ovidiu Mitu, Alexandru Dan Costache, Ana Clara Aprotosoaie

Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?

Abstract:

The antiplatelet effect of clopidogrel prodrug is characterized by a wide inter-individual variability that has a significant clinical relevance. Among varios factors that are involved in the occurrence of clopidogrel resistance, the genetic polymorphisms play a key role. The aim of the present study was to investigate the impact of some risk factors for atherosclerosis on the antiplatelet effect of clopidogrel in patients with acute coronary syndrome and the possible correlation with metabolizer phenotype of patients based on CYP2C19 polymorfisms. We found a statistically significant correlation (p value [ 0.05) between smoking or dyslipidaemia and the presence of ultrarapid metabolizer phenotype for clopidogrel in our research population.

Keywords:
clopidogrel resistance; atherosclerosis; risk factors; CYP2C19 polymorphisms

Issue: 2017, Volume 68, Issue 11

Pages: 2726-2730

Publication date: 2017/12/15

https://doi.org/10.37358/RC.17.11.5963

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
COSTACHE, I.I., MITU, F., NAMAT, R.A., IVANOV, I., POPESCU, R., MITU, O., COSTACHE, A.D., APROTOSOAIE, A.C., Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?, Rev. Chim., 68(11), 2017, 2726-2730.

Vancouver
Costache II, Mitu F, Namat RA, Ivanov I, Popescu R, Mitu O, Costache AD, Aprotosoaie AC. Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?. Rev. Chim.[internet]. 2017 Nov;68(11):2726-2730. Available from: https://doi.org/10.37358/RC.17.11.5963

APA 6th edition
Costache, I.I., Mitu, F., Namat, R.A., Ivanov, I., Popescu, R., Mitu, O., Costache, A.D. & Aprotosoaie, A.C. (2017). Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?. Revista de Chimie, 68(11), 2726-2730. https://doi.org/10.37358/RC.17.11.5963

Harvard
Costache, I.I., Mitu, F., Namat, R.A., Ivanov, I., Popescu, R., Mitu, O., Costache, A.D., Aprotosoaie, A.C. (2017). 'Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?', Revista de Chimie, 68(11), pp. 2726-2730. https://doi.org/10.37358/RC.17.11.5963

IEEE
I.I. Costache, F. Mitu, R.A. Namat, I. Ivanov, R. Popescu, O. Mitu, A.D. Costache, A.C. Aprotosoaie, "Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?". Revista de Chimie, vol. 68, no. 11, pp. 2726-2730, 2017. [online]. https://doi.org/10.37358/RC.17.11.5963

Text
Irina Iuliana Costache, Florin Mitu, Razan Al Namat, Iuliu Ivanov, Roxana Popescu, Ovidiu Mitu, Alexandru Dan Costache, Ana Clara Aprotosoaie,
Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?,
Revista de Chimie,
Volume 68, Issue 11,
2017,
Pages 2726-2730,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.11.5963.
(https://revistadechimie.ro/Articles.asp?ID=5963)
Keywords: clopidogrel resistance; atherosclerosis; risk factors; CYP2C19 polymorphisms

RIS
TY - JOUR
T1 - Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?
A1 - Costache, Irina Iuliana
A2 - Mitu, Florin
A3 - Namat, Razan Al
A4 - Ivanov, Iuliu
A5 - Popescu, Roxana
A6 - Mitu, Ovidiu
A7 - Costache, Alexandru Dan
A8 - Aprotosoaie, Ana Clara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 11
SP - 2726
EP - 2730
UR - https://doi.org/10.37358/RC.17.11.5963
KW - clopidogrel resistance
KW - atherosclerosis
KW - risk factors
KW - CYP2C19 polymorphisms
ER -

BibTex
@article{RevCh2017P2726,
author = {Costache Irina Iuliana and Mitu Florin and Namat Razan Al and Ivanov Iuliu and Popescu Roxana and Mitu Ovidiu and Costache Alexandru Dan and Aprotosoaie Ana Clara},
title = {Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?},
journal = {Revista de Chimie},
volume = {68},
number = {11},
pages = {2726-2730},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.11.5963},
url = {https://revistadechimie.ro/Articles.asp?ID=5963}
}

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