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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 12, 2808-2811

https://doi.org/10.37358/RC.17.12.5983

Karoly Mensch, Julia Pongracz, Adam Nagy, Katalin Kristof, Anamaria Bechir, Mariana Pacurar, Gabor Nagy

Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm

Abstract:

The aim of the study was to assess the preventive and therapeutic efficacy of a sustained-release varnish (SRV) Cervitec Plus® compared with Corsodyl® mouthwash against Candida albicans, Candida parapsilosis, Candida tropicalis and Candida glabrata on acrylate surfaces. Nystatin as the positive control, and sterile saline solution as the negative control, were used. To examine the preventive efficacy of the agents, Candida biofilms were developed in Sabouraud liquid medium, and mature biofilms were treated with the antifungal. To investigate the preventive efficacy, the agents were applied to the wells of the plates and the biofilms were grown in the treated wells. To determine the metabolic activity of biofilms, the XTT-assay was used. In the case of C. albicans and C. parapsilosis, the most effective therapeutic product was Corsodyl® followed by Cervitec Plus® and Nystatin. The differences were statistically significant when Corsodyl® was compared to Nystatin ( p £ 0.05). In relation to C. tropicalis and C. glabrata, Corsodyl® showed the greatest therapeutic efficacy followed by Nystatin and Cervitec Plus®. For both species, the results of Corsodyl® and Cervitec Plus® showed statistically significant difference ( p £ 0.05). The most effective preventive product for each examined Candida species was Nystatin, followed by Cervitec Plus® and Corsodyl®. Significant differences were between Nystatin and Corsodyl® (p £ 0.05). The preventive and therapeutic efficacy of Cervitec Plus® and Corsodyl®, against the examined Candida species, was detected. Because of the disadvantageous side-effects of Nystatin, Cervitec Plus® can be considered as an alternative preventive agent against Candida species.
Keywords:
Candida biofilm; denture stomatitis; sustained release varnish

Issue: 2017, Volume 68, Issue 12
Pages: 2808-2811
Publication date: 2018/1/15
https://doi.org/10.37358/RC.17.12.5983
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MENSCH, K., PONGRACZ, J., NAGY, A., KRISTOF, K., BECHIR, A., PACURAR, M., NAGY, G., Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm, Rev. Chim., 68(12), 2017, 2808-2811.

Vancouver
Mensch K, Pongracz J, Nagy A, Kristof K, Bechir A, Pacurar M, Nagy G. Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm. Rev. Chim.[internet]. 2017 Dec;68(12):2808-2811. Available from: https://doi.org/10.37358/RC.17.12.5983


APA 6th edition
Mensch, K., Pongracz, J., Nagy, A., Kristof, K., Bechir, A., Pacurar, M. & Nagy, G. (2017). Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm. Revista de Chimie, 68(12), 2808-2811. https://doi.org/10.37358/RC.17.12.5983


Harvard
Mensch, K., Pongracz, J., Nagy, A., Kristof, K., Bechir, A., Pacurar, M., Nagy, G. (2017). 'Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm', Revista de Chimie, 68(12), pp. 2808-2811. https://doi.org/10.37358/RC.17.12.5983


IEEE
K. Mensch, J. Pongracz, A. Nagy, K. Kristof, A. Bechir, M. Pacurar, G. Nagy, "Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm". Revista de Chimie, vol. 68, no. 12, pp. 2808-2811, 2017. [online]. https://doi.org/10.37358/RC.17.12.5983


Text
Karoly Mensch, Julia Pongracz, Adam Nagy, Katalin Kristof, Anamaria Bechir, Mariana Pacurar, Gabor Nagy,
Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 2808-2811,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.5983.
(https://revistadechimie.ro/Articles.asp?ID=5983)
Keywords: Candida biofilm; denture stomatitis; sustained release varnish


RIS
TY - JOUR
T1 - Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm
A1 - Mensch, Karoly
A2 - Pongracz, Julia
A3 - Nagy, Adam
A4 - Kristof, Katalin
A5 - Bechir, Anamaria
A6 - Pacurar, Mariana
A7 - Nagy, Gabor
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 2808
EP - 2811
UR - https://doi.org/10.37358/RC.17.12.5983
KW - Candida biofilm
KW - denture stomatitis
KW - sustained release varnish
ER -


BibTex
@article{RevCh2017P2808,
author = {Mensch Karoly and Pongracz Julia and Nagy Adam and Kristof Katalin and Bechir Anamaria and Pacurar Mariana and Nagy Gabor},
title = {Preventive andTherapeutic Effects of Chlorhexidine Containing Varnish on Candida Biofilm},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {2808-2811},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.5983},
url = {https://revistadechimie.ro/Articles.asp?ID=5983}
}
 
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