Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values

Navolan, Dan; Ionescu, Cringu Antoniu; Carabineanu, Adrian; Birsasteanu, Florin; Cretu, Octavian; Szasz, Florin; Vladareanu, Simona; Ciohat, Ioana; Gidea, Ramona; Nemescu, Dragos; Farcas, Simona; Andreescu, Nicoleta; Simu, Sebastian; Stoian, Dana

Dan Navolan, Cringu Antoniu Ionescu, Adrian Carabineanu, Florin Birsasteanu, Octavian Cretu, Florin Szasz, Simona Vladareanu, Ioana Ciohat, Ramona Gidea, Dragos Nemescu, Simona Farcas, Nicoleta Andreescu, Sebastian Simu, Dana Stoian

Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values

Abstract:

Values of first trimester biochemical markers (PAPP-A and free b-hCG) concentration are included in aneuploidies risk evaluation algorithm. Since both markers are produced by the fetus and placenta their concentration depends on the volume in which they are dissolved, respectively the weight of the pregnant women. Our study aimed to analyze the influence of maternal weight on first trimester biochemical markers concentration and the ability of the risk calculation software to correct this influence. Pregnancy-associated protein A (PAPP-A) and free ß chorionic gonadotropin hormone (free ß hCG) first trimester sera concentration respectively weight were measured in 1629 pregnant women. First trimester PAPP-A and free beta hCG concentrations inverse correlate with weight of pregnant women rho=-0.33, p[0.0001, respectively rho=-0.18, p[0.0001. Weight of pregnant women inversely correlates with multiple of median (MoM) values of first trimester markers too: rho=-0.38, p[0.0001 (PAPP-A), respectively rho=-0.17, p[0.0001 (free-b-hCG). The software counterbalances the influence of weight on biochemical markers values. PAPP-A corrected MoM (MoMc) values don’t inversely correlate with the weight (rho=-0.03, p=0.12), whereas free ß hCG MoMc values showed an extremely weak inverse correlation (rho=-0.08, p=0.0008). The software counterbalances the influence of weight on PAPP-A values, whereas an extremely weak but insignificant inverse correlation between weight and free-beta hCG values persists after correction.

Keywords:
PAPP-A; free b hCG; first trimester biochemical markers; aneuploidies; weight; software correction

Issue: 2017, Volume 68, Issue 12

Pages: 2836-2838

Publication date: 2018/1/15

https://doi.org/10.37358/RC.17.12.5989

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NAVOLAN, D., IONESCU, C.A., CARABINEANU, A., BIRSASTEANU, F., CRETU, O., SZASZ, F., VLADAREANU, S., CIOHAT, I., GIDEA, R., NEMESCU, D., FARCAS, S., ANDREESCU, N., SIMU, S., STOIAN, D., Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values, Rev. Chim., 68(12), 2017, 2836-2838.

Vancouver
Navolan D, Ionescu CA, Carabineanu A, Birsasteanu F, Cretu O, Szasz F, Vladareanu S, Ciohat I, Gidea R, Nemescu D, Farcas S, Andreescu N, Simu S, Stoian D. Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values. Rev. Chim.[internet]. 2017 Dec;68(12):2836-2838. Available from: https://doi.org/10.37358/RC.17.12.5989

APA 6th edition
Navolan, D., Ionescu, C.A., Carabineanu, A., Birsasteanu, F., Cretu, O., Szasz, F.,... Stoian, D. (2017). Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values. Revista de Chimie, 68(12), 2836-2838. https://doi.org/10.37358/RC.17.12.5989

Harvard
Navolan, D., Ionescu, C.A., Carabineanu, A., Birsasteanu, F., Cretu, O., Szasz, F., Vladareanu, S., Ciohat, I., Gidea, R., Nemescu, D., Farcas, S., Andreescu, N., Simu, S., Stoian, D. (2017). 'Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values', Revista de Chimie, 68(12), pp. 2836-2838. https://doi.org/10.37358/RC.17.12.5989

IEEE
D. Navolan, C.A. Ionescu, A. Carabineanu, F. Birsasteanu, O. Cretu, F. Szasz, S. Vladareanu, I. Ciohat, R. Gidea, D. Nemescu, S. Farcas, N. Andreescu, S. Simu, D. Stoian, "Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values". Revista de Chimie, vol. 68, no. 12, pp. 2836-2838, 2017. [online]. https://doi.org/10.37358/RC.17.12.5989

Text
Dan Navolan, Cringu Antoniu Ionescu, Adrian Carabineanu, Florin Birsasteanu, Octavian Cretu, Florin Szasz, Simona Vladareanu, Ioana Ciohat, Ramona Gidea, Dragos Nemescu, Simona Farcas, Nicoleta Andreescu, Sebastian Simu, Dana Stoian,
Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 2836-2838,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.5989.
(https://revistadechimie.ro/Articles.asp?ID=5989)
Keywords: PAPP-A; free b hCG; first trimester biochemical markers; aneuploidies; weight; software correction

RIS
TY - JOUR
T1 - Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values
A1 - Navolan, Dan
A2 - Ionescu, Cringu Antoniu
A3 - Carabineanu, Adrian
A4 - Birsasteanu, Florin
A5 - Cretu, Octavian
A6 - Szasz, Florin
A7 - Vladareanu, Simona
A8 - Ciohat, Ioana
A9 - Gidea, Ramona
A10 - Nemescu, Dragos
A11 - Farcas, Simona
A12 - Andreescu, Nicoleta
A13 - Simu, Sebastian
A14 - Stoian, Dana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 2836
EP - 2838
UR - https://doi.org/10.37358/RC.17.12.5989
KW - PAPP-A
KW - free b hCG
KW - first trimester biochemical markers
KW - aneuploidies
KW - weight
KW - software correction
ER -

BibTex
@article{RevCh2017P2836,
author = {Navolan Dan and Ionescu Cringu Antoniu and Carabineanu Adrian and Birsasteanu Florin and Cretu Octavian and Szasz Florin and Vladareanu Simona and Ciohat Ioana and Gidea Ramona and Nemescu Dragos and Farcas Simona and Andreescu Nicoleta and Simu Sebastian and Stoian Dana},
title = {Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {2836-2838},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.5989},
url = {https://revistadechimie.ro/Articles.asp?ID=5989}
}

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