Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?

Pricop, Catalin; Vacaroiu, Ileana Adela; Radulescu, Daniela; Andone, Daniel; Puia, Dragos

Catalin Pricop, Ileana Adela Vacaroiu, Daniela Radulescu, Daniel Andone, Dragos Puia

Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?

Abstract:

In the literature, occurrence of acute kidney injury (AKI) in young patients with unilateral ureteral lithiasic obstruction and without previous renal impairment is not very often reported, and the underlined pathophysiological mechanisms are poorly known; according to some studies, it is a false kidney failure, the increase in serum creatinine being due to absorbtion of obstructed urine in the affected kidney. We have conducted a retro and prospective study in order to identify the possible risk factors that can cause renal function impairment in young patients (18-40 years) with unilateral ureteral lithiasis obstruction and a normal contralateral kidney. Results. From 402 patients included in the study, 20.64% (83 cases) presented with serum creatinine ] 1.3 mg/dL. In patients with renal impairment, prevalence of male gender and history of NSAIDS use before admission were significantly higher than in non-AKI group. Serum urea/creatinine ratio, and estimated glomerular filtration rate (MDRD formula) were significantly higher, and respectively lower in AKI group. We found no significant differences between the two groups regarding age, prevalence of urinary tract infection after relief of obstruction, C-reactive protein value, and the duration of hospitalization. Conclusions. AKI in young patients with unilateral ureteral lithiasis obstruction and normal contralateral kidney is not quite a rare finding in our region. NSAIDs use can influence development of AKI, and should be used cautiously even in young patients with renal colic. In our opinion, the presence of AKI in patients with unilateral hydronephrosis demands urgent endourological intervention. Choosing conservative therapy in these patients, especially treatment with NSAIDS may aggravate the renal dysfunction.

Keywords:
unilateral ureteral obstruction; normal contralateral kidney; acute renal injury; NSAIDS

Issue: 2018, Volume 69, Issue 2

Pages: 375-378

Publication date: 2018/3/15

https://doi.org/10.37358/RC.18.2.6110

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PRICOP, C., VACAROIU, I.A., RADULESCU, D., ANDONE, D., PUIA, D., Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?, Rev. Chim., 69(2), 2018, 375-378.

Vancouver
Pricop C, Vacaroiu IA, Radulescu D, Andone D, Puia D. Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?. Rev. Chim.[internet]. 2018 Feb;69(2):375-378. Available from: https://doi.org/10.37358/RC.18.2.6110

APA 6th edition
Pricop, C., Vacaroiu, I.A., Radulescu, D., Andone, D. & Puia, D. (2018). Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?. Revista de Chimie, 69(2), 375-378. https://doi.org/10.37358/RC.18.2.6110

Harvard
Pricop, C., Vacaroiu, I.A., Radulescu, D., Andone, D., Puia, D. (2018). 'Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?', Revista de Chimie, 69(2), pp. 375-378. https://doi.org/10.37358/RC.18.2.6110

IEEE
C. Pricop, I.A. Vacaroiu, D. Radulescu, D. Andone, D. Puia, "Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?". Revista de Chimie, vol. 69, no. 2, pp. 375-378, 2018. [online]. https://doi.org/10.37358/RC.18.2.6110

Text
Catalin Pricop, Ileana Adela Vacaroiu, Daniela Radulescu, Daniel Andone, Dragos Puia,
Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?,
Revista de Chimie,
Volume 69, Issue 2,
2018,
Pages 375-378,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.2.6110.
(https://revistadechimie.ro/Articles.asp?ID=6110)
Keywords: unilateral ureteral obstruction; normal contralateral kidney; acute renal injury; NSAIDS

RIS
TY - JOUR
T1 - Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?
A1 - Pricop, Catalin
A2 - Vacaroiu, Ileana Adela
A3 - Radulescu, Daniela
A4 - Andone, Daniel
A5 - Puia, Dragos
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 2
SP - 375
EP - 378
UR - https://doi.org/10.37358/RC.18.2.6110
KW - unilateral ureteral obstruction
KW - normal contralateral kidney
KW - acute renal injury
KW - NSAIDS
ER -

BibTex
@article{RevCh2018P375,
author = {Pricop Catalin and Vacaroiu Ileana Adela and Radulescu Daniela and Andone Daniel and Puia Dragos},
title = {Renal Impairment in Young Patients with Unilateral Ureteral Lithiasis Obstruction: What Factors can be Responsible?},
journal = {Revista de Chimie},
volume = {69},
number = {2},
pages = {375-378},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.2.6110},
url = {https://revistadechimie.ro/Articles.asp?ID=6110}
}

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