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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 2, 529-532

https://doi.org/10.37358/RC.18.2.6141

Florin Szasz, Codrina Levai, Dan Navolan, Simona Farcas, Nicoleta Andreescu, Florin Birsasteanu, Claudia Mehedintu, Cringu Antoniu Ionescu, Roxana Bohiltea, Adrian Carabineanu, Dragos Nemescu, Sebastian Simu, Dana Stoian

Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers

Abstract:

Fetal aneuploidies screening was based for a long time on ultrasonographic and biochemical markers measurement. The risk calculated in accordance with second trimester biochemical markers (STBM) values relies on calculation of corrected MoM values. MoM (multiple of Medians) signify the deviation of a measured value from the expected value (Median). The Median is measured at the same gestational age in pregnancies which involve healthy fetuses. The correction of MoM includes an adjustment for certain parameters that influence the STBM value: demographical (ethnicity), behavioral (smoking status, weight), and others (mode of conceiving, etc.). In our article we aim to analyze: (1) the accuracy of software to calculate STBM corrected MoM values, (2) the effect of weight of pregnant women on STBM and (3) the capability of software to counterbalance this influence. Pregnant women (n=1242) were screened for aneuploidies based on an integrated test: first trimester ultrasound and STBM (AFP, hCG and uE3). The absolute value, multiple of median (MoM) and corrected multiple of median (MoMc) values were 33.94±0.45, 1.04±0.12 and 0.98±0.01 for AFP, 22530±477, 0.87±0.01 and 0.85±0.01 for hCG, respectively 0.97±0.03, 0.99±0.01 and 0.98±0.01 for uE3. The weight of pregnant women inversely correlates with absolute and MoM AFP, hCG and uE3 values. No correlation was found with AFP and hCG MoMc values. A very weak inverse correlation was found between weight and uE3 corrected MoM values. Our study confirms that there is a difference between provider and own calculated hCG MoMc values. The weight of pregnant women inversely correlates with STBM values. The software used for aneuploidies risk evaluation corrects the influence of weight of pregnant women, but a minimal influence on uE3 corrected MoM values is still present.
Keywords:
AFP; hCG; uE3; influence of weight; integrated screening; aneuploidies; software correction

Issue: 2018, Volume 69, Issue 2
Pages: 529-532
Publication date: 2018/3/15
https://doi.org/10.37358/RC.18.2.6141
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SZASZ, F., LEVAI, C., NAVOLAN, D., FARCAS, S., ANDREESCU, N., BIRSASTEANU, F., MEHEDINTU, C., IONESCU, C.A., BOHILTEA, R., CARABINEANU, A., NEMESCU, D., SIMU, S., STOIAN, D., Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers, Rev. Chim., 69(2), 2018, 529-532.

Vancouver
Szasz F, Levai C, Navolan D, Farcas S, Andreescu N, Birsasteanu F, Mehedintu C, Ionescu CA, Bohiltea R, Carabineanu A, Nemescu D, Simu S, Stoian D. Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers. Rev. Chim.[internet]. 2018 Feb;69(2):529-532. Available from: https://doi.org/10.37358/RC.18.2.6141


APA 6th edition
Szasz, F., Levai, C., Navolan, D., Farcas, S., Andreescu, N., Birsasteanu, F.,... Stoian, D. (2018). Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers. Revista de Chimie, 69(2), 529-532. https://doi.org/10.37358/RC.18.2.6141


Harvard
Szasz, F., Levai, C., Navolan, D., Farcas, S., Andreescu, N., Birsasteanu, F., Mehedintu, C., Ionescu, C.A., Bohiltea, R., Carabineanu, A., Nemescu, D., Simu, S., Stoian, D. (2018). 'Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers', Revista de Chimie, 69(2), pp. 529-532. https://doi.org/10.37358/RC.18.2.6141


IEEE
F. Szasz, C. Levai, D. Navolan, S. Farcas, N. Andreescu, F. Birsasteanu, C. Mehedintu, C.A. Ionescu, R. Bohiltea, A. Carabineanu, D. Nemescu, S. Simu, D. Stoian, "Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers". Revista de Chimie, vol. 69, no. 2, pp. 529-532, 2018. [online]. https://doi.org/10.37358/RC.18.2.6141


Text
Florin Szasz, Codrina Levai, Dan Navolan, Simona Farcas, Nicoleta Andreescu, Florin Birsasteanu, Claudia Mehedintu, Cringu Antoniu Ionescu, Roxana Bohiltea, Adrian Carabineanu, Dragos Nemescu, Sebastian Simu, Dana Stoian,
Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers,
Revista de Chimie,
Volume 69, Issue 2,
2018,
Pages 529-532,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.2.6141.
(https://revistadechimie.ro/Articles.asp?ID=6141)
Keywords: AFP; hCG; uE3; influence of weight; integrated screening; aneuploidies; software correction


RIS
TY - JOUR
T1 - Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers
A1 - Szasz, Florin
A2 - Levai, Codrina
A3 - Navolan, Dan
A4 - Farcas, Simona
A5 - Andreescu, Nicoleta
A6 - Birsasteanu, Florin
A7 - Mehedintu, Claudia
A8 - Ionescu, Cringu Antoniu
A9 - Bohiltea, Roxana
A10 - Carabineanu, Adrian
A11 - Nemescu, Dragos
A12 - Simu, Sebastian
A13 - Stoian, Dana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 2
SP - 529
EP - 532
UR - https://doi.org/10.37358/RC.18.2.6141
KW - AFP
KW - hCG
KW - uE3
KW - influence of weight
KW - integrated screening
KW - aneuploidies
KW - software correction
ER -


BibTex
@article{RevCh2018P529,
author = {Szasz Florin and Levai Codrina and Navolan Dan and Farcas Simona and Andreescu Nicoleta and Birsasteanu Florin and Mehedintu Claudia and Ionescu Cringu Antoniu and Bohiltea Roxana and Carabineanu Adrian and Nemescu Dragos and Simu Sebastian and Stoian Dana},
title = {Weight of Pregnant Women and their Influence on Second Trimester Biochemical Markers},
journal = {Revista de Chimie},
volume = {69},
number = {2},
pages = {529-532},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.2.6141},
url = {https://revistadechimie.ro/Articles.asp?ID=6141}
}
 
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