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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 3, 627-631

https://doi.org/10.37358/RC.18.3.6163

Viorica Ohriac (Popa), Diana Cimpoesu, Adrian Florin Spac, Paul Nedelea, Voichita Lazureanu, Oana Suciu, Tudor Ovidiu Popa, Elena Butnaru

The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples

Abstract:

Pain is defined as a disagreeable sensory and emotional experience related to a tissue or potential lesion. Paracetamol (Acetaminophen) is the most used non-morphine analgesic. For the determination of paracetamol we developed and validated the high performance liquid chromatography (HPLC) analysis using a Dionex Ultimate 3000 liquid chromatograph equipped with a multidimensional detector. After determining the optimum conditions of analysis (80/20 water / acetonitrile mobile phase, flow rate 1.0 mL / min, detection wavelength 245 nm) we validated the method following the following parameters: linearity of response function, linearity of results, limit (LD = 0.66 mg / mL) and quantification limit (LQ = 2.00 mg / mL), and precision. The method of determining paracetamol by HPLC was applied to 30 samples of serum collected from patients who had pain and were treated with paracetamol.
Keywords:
paracetamol; HPLC; ser

Issue: 2018, Volume 69, Issue 3
Pages: 627-631
Publication date: 2018/4/15
https://doi.org/10.37358/RC.18.3.6163
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
OHRIAC (POPA), V., CIMPOESU, D., SPAC, A.F., NEDELEA, P., LAZUREANU, V., SUCIU, O., POPA, T.O., BUTNARU, E., The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples, Rev. Chim., 69(3), 2018, 627-631.

Vancouver
Ohriac (Popa) V, Cimpoesu D, Spac AF, Nedelea P, Lazureanu V, Suciu O, Popa TO, Butnaru E. The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples. Rev. Chim.[internet]. 2018 Mar;69(3):627-631. Available from: https://doi.org/10.37358/RC.18.3.6163


APA 6th edition
Ohriac (Popa), V., Cimpoesu, D., Spac, A.F., Nedelea, P., Lazureanu, V., Suciu, O., Popa, T.O. & Butnaru, E. (2018). The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples. Revista de Chimie, 69(3), 627-631. https://doi.org/10.37358/RC.18.3.6163


Harvard
Ohriac (Popa), V., Cimpoesu, D., Spac, A.F., Nedelea, P., Lazureanu, V., Suciu, O., Popa, T.O., Butnaru, E. (2018). 'The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples', Revista de Chimie, 69(3), pp. 627-631. https://doi.org/10.37358/RC.18.3.6163


IEEE
V. Ohriac(Popa), D. Cimpoesu, A.F. Spac, P. Nedelea, V. Lazureanu, O. Suciu, T.O. Popa, E. Butnaru, "The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples". Revista de Chimie, vol. 69, no. 3, pp. 627-631, 2018. [online]. https://doi.org/10.37358/RC.18.3.6163


Text
Viorica Ohriac(Popa), Diana Cimpoesu, Adrian Florin Spac, Paul Nedelea, Voichita Lazureanu, Oana Suciu, Tudor Ovidiu Popa, Elena Butnaru,
The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 627-631,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6163.
(https://revistadechimie.ro/Articles.asp?ID=6163)
Keywords: paracetamol; HPLC; ser


RIS
TY - JOUR
T1 - The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples
A1 - Ohriac (Popa), Viorica
A2 - Cimpoesu, Diana
A3 - Spac, Adrian Florin
A4 - Nedelea, Paul
A5 - Lazureanu, Voichita
A6 - Suciu, Oana
A7 - Popa, Tudor Ovidiu
A8 - Butnaru, Elena
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 627
EP - 631
UR - https://doi.org/10.37358/RC.18.3.6163
KW - paracetamol
KW - HPLC
KW - ser
ER -


BibTex
@article{RevCh2018P627,
author = {Ohriac (Popa) Viorica and Cimpoesu Diana and Spac Adrian Florin and Nedelea Paul and Lazureanu Voichita and Suciu Oana and Popa Tudor Ovidiu and Butnaru Elena},
title = {The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {627-631},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6163},
url = {https://revistadechimie.ro/Articles.asp?ID=6163}
}
 
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