The Role of Chromogranin A in Adrenal Tumors

Mirica, Alexandra; Badarau, Ioana Anca; Stefanescu, Ana Maria; Mirica, Radu; Paun, Sorin; Stefan, Daciana Andrada Costina; Paun, Diana Loreta

Alexandra Mirica, Ioana Anca Badarau, Ana Maria Stefanescu, Radu Mirica, Sorin Paun, Daciana Andrada Costina Stefan, Diana Loreta Paun

The Role of Chromogranin A in Adrenal Tumors

Abstract:

Chromogranin A (CgA) is part of the family of granins, which are acidic glycoproteins that represent an important part of secretory dense core granules. They are specific to various neuroendocrine and endocrine tissues, as components of diffuse neuroendocrine system and endocrine glands. CgA is co-secreted and co-released in the circulation along with hormones, bioamines and peptides secreted from the neuroendocrine cells . In the last decade, studies have emphasized the major importance of serum CgA in the diagnosis and follow-up of neuroendocrine tumors such as gastroenteropancreatic tumors, pheochromocytoma, medullary thyroid carcinoma. But its diagnostic value for adrenocortical adenomas or for adrenal malignancy, is still controversial. The current study aims to provide a comprehensive review , for synthesizing current knowledge regarding corelations between plasma CgA concentration and various adrenal tumors. Furthermore, there will be also analyzed and synthesized the clinical applicability and the diagnostic usefulness of dosing CgA in adrenal pathology, both medullary and cortical benign and malignant lesions.

Keywords:
chromogranin A; pheochromocytoma; adrenocortical secretory adenomas; non-functioning adrenocortical tumors; adrenal neoplasia

Issue: 2018, Volume 69, Issue 3

Pages: 678-681

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6174

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIRICA, A., BADARAU, I.A., STEFANESCU, A.M., MIRICA, R., PAUN, S., STEFAN, D.A.C., PAUN, D.L., The Role of Chromogranin A in Adrenal Tumors, Rev. Chim., 69(3), 2018, 678-681.

Vancouver
Mirica A, Badarau IA, Stefanescu AM, Mirica R, Paun S, Stefan DAC, Paun DL. The Role of Chromogranin A in Adrenal Tumors. Rev. Chim.[internet]. 2018 Mar;69(3):678-681. Available from: https://doi.org/10.37358/RC.18.3.6174

APA 6th edition
Mirica, A., Badarau, I.A., Stefanescu, A.M., Mirica, R., Paun, S., Stefan, D.A.C. & Paun, D.L. (2018). The Role of Chromogranin A in Adrenal Tumors. Revista de Chimie, 69(3), 678-681. https://doi.org/10.37358/RC.18.3.6174

Harvard
Mirica, A., Badarau, I.A., Stefanescu, A.M., Mirica, R., Paun, S., Stefan, D.A.C., Paun, D.L. (2018). 'The Role of Chromogranin A in Adrenal Tumors', Revista de Chimie, 69(3), pp. 678-681. https://doi.org/10.37358/RC.18.3.6174

IEEE
A. Mirica, I.A. Badarau, A.M. Stefanescu, R. Mirica, S. Paun, D.A.C. Stefan, D.L. Paun, "The Role of Chromogranin A in Adrenal Tumors". Revista de Chimie, vol. 69, no. 3, pp. 678-681, 2018. [online]. https://doi.org/10.37358/RC.18.3.6174

Text
Alexandra Mirica, Ioana Anca Badarau, Ana Maria Stefanescu, Radu Mirica, Sorin Paun, Daciana Andrada Costina Stefan, Diana Loreta Paun,
The Role of Chromogranin A in Adrenal Tumors,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 678-681,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6174.
(https://revistadechimie.ro/Articles.asp?ID=6174)
Keywords: chromogranin A; pheochromocytoma; adrenocortical secretory adenomas; non-functioning adrenocortical tumors; adrenal neoplasia

RIS
TY - JOUR
T1 - The Role of Chromogranin A in Adrenal Tumors
A1 - Mirica, Alexandra
A2 - Badarau, Ioana Anca
A3 - Stefanescu, Ana Maria
A4 - Mirica, Radu
A5 - Paun, Sorin
A6 - Stefan, Daciana Andrada Costina
A7 - Paun, Diana Loreta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 678
EP - 681
UR - https://doi.org/10.37358/RC.18.3.6174
KW - chromogranin A
KW - pheochromocytoma
KW - adrenocortical secretory adenomas
KW - non-functioning adrenocortical tumors
KW - adrenal neoplasia
ER -

BibTex
@article{RevCh2018P678,
author = {Mirica Alexandra and Badarau Ioana Anca and Stefanescu Ana Maria and Mirica Radu and Paun Sorin and Stefan Daciana Andrada Costina and Paun Diana Loreta},
title = {The Role of Chromogranin A in Adrenal Tumors},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {678-681},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6174},
url = {https://revistadechimie.ro/Articles.asp?ID=6174}
}

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