The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders

Badulescu, Oana Viola; Vintila, Dan; Sirbu, Paul Dan; Ciuntu, Bogdan Mihnea

Oana Viola Badulescu, Dan Vintila, Paul Dan Sirbu, Bogdan Mihnea Ciuntu

The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders

Abstract:

Polycythaemia vera (PV) is a monoclonal myeloproliferative disorder characterized by a haemostatic imbalance resulting in increased risk for thrombotic events. In PV there is an important affection of the vascular endothelium, so we analized in our study three markers of endothelium disfunction- von Willbrand factor (vWF), Protein C (PC) and the inhibitor plasminogen activator type-1. (PAI-1) The study comprised 40 patients and the objective of the study was to investigate the level of the mentioned parameters in two groups of patients-the group of polycytemic patients without cardiovascular diseases (PV) and the group of polycitemic patients with cardiovascular pathology associated (PV+CVD). The levels of the studied parameters were found significantly modified in the PV group (p[0.05); for the PV+CVD group the level of vWF was higher (p[0.001), but the levels of the other parameters, didn’t show a significant statistic difference compared with the first group (p]0.05). In accordance with the presented results, the conclusions of our study was that in PV the risk of thrombotic accidents is related by the increase of the vWF level, as the vascular endothelium plays a key role in this pathology.

Keywords:
chromogenic assay; immunoturbidimetry assay; thrombosis; Protein C; enzymatic immunoassay

Issue: 2018, Volume 69, Issue 3

Pages: 744-746

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6190

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., VINTILA, D., SIRBU, P.D., CIUNTU, B.M., The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders, Rev. Chim., 69(3), 2018, 744-746.

Vancouver
Badulescu OV, Vintila D, Sirbu PD, Ciuntu BM. The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders. Rev. Chim.[internet]. 2018 Mar;69(3):744-746. Available from: https://doi.org/10.37358/RC.18.3.6190

APA 6th edition
Badulescu, O.V., Vintila, D., Sirbu, P.D. & Ciuntu, B.M. (2018). The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders. Revista de Chimie, 69(3), 744-746. https://doi.org/10.37358/RC.18.3.6190

Harvard
Badulescu, O.V., Vintila, D., Sirbu, P.D., Ciuntu, B.M. (2018). 'The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders', Revista de Chimie, 69(3), pp. 744-746. https://doi.org/10.37358/RC.18.3.6190

IEEE
O.V. Badulescu, D. Vintila, P.D. Sirbu, B.M. Ciuntu, "The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders". Revista de Chimie, vol. 69, no. 3, pp. 744-746, 2018. [online]. https://doi.org/10.37358/RC.18.3.6190

Text
Oana Viola Badulescu, Dan Vintila, Paul Dan Sirbu, Bogdan Mihnea Ciuntu,
The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 744-746,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6190.
(https://revistadechimie.ro/Articles.asp?ID=6190)
Keywords: chromogenic assay; immunoturbidimetry assay; thrombosis; Protein C; enzymatic immunoassay

RIS
TY - JOUR
T1 - The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders
A1 - Badulescu, Oana Viola
A2 - Vintila, Dan
A3 - Sirbu, Paul Dan
A4 - Ciuntu, Bogdan Mihnea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 744
EP - 746
UR - https://doi.org/10.37358/RC.18.3.6190
KW - chromogenic assay; immunoturbidimetry assay
KW - thrombosis; Protein C
KW - enzymatic immunoassay
ER -

BibTex
@article{RevCh2018P744,
author = {Badulescu Oana Viola and Vintila Dan and Sirbu Paul Dan and Ciuntu Bogdan Mihnea},
title = {The Role of Chromogenic and Immunoturbidimetry Assays in Diagnostic of Thrombotic State in Myeloproliferative Disorders},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {744-746},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6190},
url = {https://revistadechimie.ro/Articles.asp?ID=6190}
}

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