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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 4, 915-920

https://doi.org/10.37358/RC.18.4.6227

Petronela Cristina Chiriac, Vladimir Poroch, Alina Mihaela Pascu, Mircea Daniel Hogea, Ileana Antohe, Vasile Valeriu Lupu, Valentin Cirlig

Antibiotic Molecules Efficacy in Pediatric Bacterial Infections

Abstract:

The antibiotic resistance of microorganisms involved in pediatric infections represents a significant cause of healthcare-associated infections (HAIs), and is also a matter of management, requiring specific intervention. The aim of the study was to evaluate the efficacy of some antibiotic molecules on pathogens isolated from patients admitted in a pediatric hospital. We carried out a descriptive study on a group of 411 patients admitted to the Sf. MariaClinical Emergency Hospital for Children Iasi, between January 1st and March 31st, 2016. Bacterial infections were most prevalent in the age group of 0-1 year (54.98% of the total isolates). Most affected by multidrug-resistant bacterial infections services were: general pediatrics (24.08% of the total isolates), then the intensive care unit (19.95%), surgical wards (14.84%), and acute therapy (11.43%). The germs were isolated from pathological samples: most often pus (23.85%), hypo-pharyngeal aspiration (21.65%), conjunctival secretion (12.42%), and ear secretion (9.48%). Penicillin G and oxacillin were inefficient in 30.26% of the Staphylococcus aureus strains, while erythromycin in 18.42%. Antibiotic resistance of Streptococcus pneumoniae was observed for penicillin G in 7.14% of the strains, while for erythromycin in 13.09%. Klebsiella pneumoniae strains were resistant to amoxicillin + clavulanic acid in 35.85% of the cases, and to cefuroxime, ceftazidime, ceftriaxone, cefepime in 33.96%. Our study highlighted that Staphylococcus aureus was resistant to penicillin G and oxacillin in more than one-third of the isolates, Streptococcus pneumoniae was resistant to penicillin G and erythromycin, and Klebsiella pneumoniae to amoxicillin + clavulanic acid and 1st, 2nd and 3rd generation cephalosporins. Continuing antibioresistance monitoring is crucial in order to promote appropriate guidelines in antibiotic prescription, which could result in decreasing HAIs’ rates.
Keywords:
antibiotic molecules; multidrug resistant (MDR) bacteria; healthcare-associated infections (HAIs)

Issue: 2018, Volume 69, Issue 4
Pages: 915-920
Publication date: 2018/5/15
https://doi.org/10.37358/RC.18.4.6227
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CHIRIAC, P.C., POROCH, V., PASCU, A.M., HOGEA, M.D., ANTOHE, I., LUPU, V.V., CIRLIG, V., Antibiotic Molecules Efficacy in Pediatric Bacterial Infections, Rev. Chim., 69(4), 2018, 915-920.

Vancouver
Chiriac PC, Poroch V, Pascu AM, Hogea MD, Antohe I, Lupu VV, Cirlig V. Antibiotic Molecules Efficacy in Pediatric Bacterial Infections. Rev. Chim.[internet]. 2018 Apr;69(4):915-920. Available from: https://doi.org/10.37358/RC.18.4.6227


APA 6th edition
Chiriac, P.C., Poroch, V., Pascu, A.M., Hogea, M.D., Antohe, I., Lupu, V.V. & Cirlig, V. (2018). Antibiotic Molecules Efficacy in Pediatric Bacterial Infections. Revista de Chimie, 69(4), 915-920. https://doi.org/10.37358/RC.18.4.6227


Harvard
Chiriac, P.C., Poroch, V., Pascu, A.M., Hogea, M.D., Antohe, I., Lupu, V.V., Cirlig, V. (2018). 'Antibiotic Molecules Efficacy in Pediatric Bacterial Infections', Revista de Chimie, 69(4), pp. 915-920. https://doi.org/10.37358/RC.18.4.6227


IEEE
P.C. Chiriac, V. Poroch, A.M. Pascu, M.D. Hogea, I. Antohe, V.V. Lupu, V. Cirlig, "Antibiotic Molecules Efficacy in Pediatric Bacterial Infections". Revista de Chimie, vol. 69, no. 4, pp. 915-920, 2018. [online]. https://doi.org/10.37358/RC.18.4.6227


Text
Petronela Cristina Chiriac, Vladimir Poroch, Alina Mihaela Pascu, Mircea Daniel Hogea, Ileana Antohe, Vasile Valeriu Lupu, Valentin Cirlig,
Antibiotic Molecules Efficacy in Pediatric Bacterial Infections,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 915-920,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6227.
(https://revistadechimie.ro/Articles.asp?ID=6227)
Keywords: antibiotic molecules; multidrug resistant (MDR) bacteria; healthcare-associated infections (HAIs)


RIS
TY - JOUR
T1 - Antibiotic Molecules Efficacy in Pediatric Bacterial Infections
A1 - Chiriac, Petronela Cristina
A2 - Poroch, Vladimir
A3 - Pascu, Alina Mihaela
A4 - Hogea, Mircea Daniel
A5 - Antohe, Ileana
A6 - Lupu, Vasile Valeriu
A7 - Cirlig, Valentin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 915
EP - 920
UR - https://doi.org/10.37358/RC.18.4.6227
KW - antibiotic molecules
KW - multidrug resistant (MDR) bacteria
KW - healthcare-associated infections (HAIs)
ER -


BibTex
@article{RevCh2018P915,
author = {Chiriac Petronela Cristina and Poroch Vladimir and Pascu Alina Mihaela and Hogea Mircea Daniel and Antohe Ileana and Lupu Vasile Valeriu and Cirlig Valentin},
title = {Antibiotic Molecules Efficacy in Pediatric Bacterial Infections},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {915-920},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6227},
url = {https://revistadechimie.ro/Articles.asp?ID=6227}
}
 
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