The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications

Badulescu, Oana Viola; Vintila, Dan; Ciuntu, Bogdan Mihnea; Ciocoiu, Manuela; Sirbu, Paul Dan

Oana Viola Badulescu, Dan Vintila, Bogdan Mihnea Ciuntu, Manuela Ciocoiu, Paul Dan Sirbu

The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications

Abstract:

Hemophilia is a pathologycharacterized by a disturbance in the normal clotting process of the blood, as a result of a functional deficit of clotting factor VIII or IX.There are two types of hemophilia: type A and type B, the former expressing a deficit of factor VIII, while the latter a deficit of factor IX.C.L., a 43 years old male, was diagnosed at the age of 8 months with a severe form of type A hemophilia. From that time, the patient presentedhemorrhagic episodes, resulting either from trauma or appearing spontaneously and requiring factor VIII substitution therapy and hemostatic treatment.Bloodwork show a prolonged aPTT, as well as microcytic anemia with a low iron serum level, as a result of chronic blood loss.The particularity of this case consists in the high degree of development and recurrence of hemophilia associated complications, leading to superior and inferior limb motor deficits and chronic pain which is currently managed with opioid medication. Also,the patient suffers from chronic hepatitis due to infection with B and C hepatitis viruses as a result of previous lifesaving plasma substitution therapy.Even though the clinical manifestations of hemophilia excert a high cost on the patient’s life as well as the medical system, timely prophylactic factor VIII substitution therapy from the moment of diagnosis until the age of 18 can reduce both the toll on the patient’s health and quality of life and also on the medical costs. Thus, we stress the fact that prophylactic therapy can have a beneficial effect both on patient’s life and also on the health system.

Keywords:
Hemophilia; clottingfactor VIII; hemostatic treatment; chronic pain

Issue: 2018, Volume 69, Issue 4

Pages: 994-996

Publication date: 2018/5/15

https://doi.org/10.37358/RC.18.4.6244

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., VINTILA, D., CIUNTU, B.M., CIOCOIU, M., SIRBU, P.D., The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications, Rev. Chim., 69(4), 2018, 994-996.

Vancouver
Badulescu OV, Vintila D, Ciuntu BM, Ciocoiu M, Sirbu PD. The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications. Rev. Chim.[internet]. 2018 Apr;69(4):994-996. Available from: https://doi.org/10.37358/RC.18.4.6244

APA 6th edition
Badulescu, O.V., Vintila, D., Ciuntu, B.M., Ciocoiu, M. & Sirbu, P.D. (2018). The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications. Revista de Chimie, 69(4), 994-996. https://doi.org/10.37358/RC.18.4.6244

Harvard
Badulescu, O.V., Vintila, D., Ciuntu, B.M., Ciocoiu, M., Sirbu, P.D. (2018). 'The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications', Revista de Chimie, 69(4), pp. 994-996. https://doi.org/10.37358/RC.18.4.6244

IEEE
O.V. Badulescu, D. Vintila, B.M. Ciuntu, M. Ciocoiu, P.D. Sirbu, "The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications". Revista de Chimie, vol. 69, no. 4, pp. 994-996, 2018. [online]. https://doi.org/10.37358/RC.18.4.6244

Text
Oana Viola Badulescu, Dan Vintila, Bogdan Mihnea Ciuntu, Manuela Ciocoiu, Paul Dan Sirbu,
The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 994-996,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6244.
(https://revistadechimie.ro/Articles.asp?ID=6244)
Keywords: Hemophilia; clottingfactor VIII; hemostatic treatment; chronic pain

RIS
TY - JOUR
T1 - The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications
A1 - Badulescu, Oana Viola
A2 - Vintila, Dan
A3 - Ciuntu, Bogdan Mihnea
A4 - Ciocoiu, Manuela
A5 - Sirbu, Paul Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 994
EP - 996
UR - https://doi.org/10.37358/RC.18.4.6244
KW - Hemophilia
KW - clottingfactor VIII
KW - hemostatic treatment
KW - chronic pain
ER -

BibTex
@article{RevCh2018P994,
author = {Badulescu Oana Viola and Vintila Dan and Ciuntu Bogdan Mihnea and Ciocoiu Manuela and Sirbu Paul Dan},
title = {The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {994-996},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6244},
url = {https://revistadechimie.ro/Articles.asp?ID=6244}
}

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