Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity

Dobrescu, Amadeus; Stoica, Laurian; Mituletu, Mihai; Isaic, Alexandru; Duta, Ciprian; Verdes, Gabriel; Tarta, Cristi; Heghes, Alina; Fulger, Lazar

Amadeus Dobrescu, Laurian Stoica, Mihai Mituletu, Alexandru Isaic, Ciprian Duta, Gabriel Verdes, Cristi Tarta, Alina Heghes, Lazar Fulger

Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity

Abstract:

Sleeve gastrectomy (SG) and gastric plication (GP) are surgical procedures providing weight loss through several mechanisms incompletely understood. Rat models allow the possibility of tight regulation of experimental conditions, making them the ideal candidates for animal models in bariatric surgery. The aim of this study was to compare the weight and metabolic changes between sleeve gastrectomy and gastric plication in a rat model with type 2 induced diabetes mellitus and obesity. Fifteen male Wistar rats were fed with DIO food (Bio Serv ÒF3282 - Mouse Diet, High Fat, Fat Calories -60%), after 36 weeks were allocated to the study three arms-SG, GP and sham operation (SO). Four weeks after the surgery the rats were weighted again. Blood tests were performed before surgery and four weeks after surgery searching for blood glucose, total cholesterol, HDL, triglycerides, and LDL. At the onset of the study, the rats were 9 weeks old and had an average body mass of 231.6g ± 31.58. After 36 weeks of DIO, one day preoperatively body weight was 774.93g ± 95.02. The preoperatively average of body weight in the SG group was 777.4g ±104.66, 775.4 g ±104.6 in the GP group, respectively 772g ±79 in the SO group. 4 weeks after surgery the mean body weight in the SG group was 648.8g ±99.09, in the GP group was 695.6g ±99.09, respectively 825.4g ±79.87 in the SO fed ad libitum group. There was a significant decrease of mean fasting glucose levels at 4 weeks postoperative in the SG group compared to the SO group (87.4mg/dL±8.73 versus 103.6 mg/dlL±4.66, p= 0.01). The same trend of mean fasting glucose was registered in the GP group versus the SO group (92.8 ± 5.67 mg/dl vs 103.6 mg/dl ± 4.66, p=0.01). Our study provides evidence of the positive effects of bariatric surgery for treating patients with morbid obesity associated with diabetes mellitus and dyslipidemia and the use of rats to study the mechanisms of weight reduction and metabolic changes in bariatric surgery.

Keywords:
sleeve gastrectomy; gastric plication; metabolic changes; dyslipidemia

Issue: 2018, Volume 69, Issue 4

Pages: 1030-1033

Publication date: 2018/5/15

https://doi.org/10.37358/RC.18.4.6253

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DOBRESCU, A., STOICA, L., MITULETU, M., ISAIC, A., DUTA, C., VERDES, G., TARTA, C., HEGHES, A., FULGER, L., Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity, Rev. Chim., 69(4), 2018, 1030-1033.

Vancouver
Dobrescu A, Stoica L, Mituletu M, Isaic A, Duta C, Verdes G, Tarta C, Heghes A, Fulger L. Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity. Rev. Chim.[internet]. 2018 Apr;69(4):1030-1033. Available from: https://doi.org/10.37358/RC.18.4.6253

APA 6th edition
Dobrescu, A., Stoica, L., Mituletu, M., Isaic, A., Duta, C., Verdes, G.,... Fulger, L. (2018). Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity. Revista de Chimie, 69(4), 1030-1033. https://doi.org/10.37358/RC.18.4.6253

Harvard
Dobrescu, A., Stoica, L., Mituletu, M., Isaic, A., Duta, C., Verdes, G., Tarta, C., Heghes, A., Fulger, L. (2018). 'Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity', Revista de Chimie, 69(4), pp. 1030-1033. https://doi.org/10.37358/RC.18.4.6253

IEEE
A. Dobrescu, L. Stoica, M. Mituletu, A. Isaic, C. Duta, G. Verdes, C. Tarta, A. Heghes, L. Fulger, "Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity". Revista de Chimie, vol. 69, no. 4, pp. 1030-1033, 2018. [online]. https://doi.org/10.37358/RC.18.4.6253

Text
Amadeus Dobrescu, Laurian Stoica, Mihai Mituletu, Alexandru Isaic, Ciprian Duta, Gabriel Verdes, Cristi Tarta, Alina Heghes, Lazar Fulger,
Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 1030-1033,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6253.
(https://revistadechimie.ro/Articles.asp?ID=6253)
Keywords: sleeve gastrectomy; gastric plication; metabolic changes; dyslipidemia

RIS
TY - JOUR
T1 - Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity
A1 - Dobrescu, Amadeus
A2 - Stoica, Laurian
A3 - Mituletu, Mihai
A4 - Isaic, Alexandru
A5 - Duta, Ciprian
A6 - Verdes, Gabriel
A7 - Tarta, Cristi
A8 - Heghes, Alina
A9 - Fulger, Lazar
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 1030
EP - 1033
UR - https://doi.org/10.37358/RC.18.4.6253
KW - sleeve gastrectomy
KW - gastric plication
KW - metabolic changes
KW - dyslipidemia
ER -

BibTex
@article{RevCh2018P1030,
author = {Dobrescu Amadeus and Stoica Laurian and Mituletu Mihai and Isaic Alexandru and Duta Ciprian and Verdes Gabriel and Tarta Cristi and Heghes Alina and Fulger Lazar},
title = {Metabolic and Weight Changes After Bariatric Surgery in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {1030-1033},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6253},
url = {https://revistadechimie.ro/Articles.asp?ID=6253}
}

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